Finco D R, Rawlings C A, Barsanti J A, Crowell W A
Am J Vet Res. 1985 Nov;46(11):2327-31.
In 6 pairs of sibling Beagle dogs, 1 kidney was exchanged between pairs, and contralateral nephrectomy was done. Previously, one dog of each pair was given blood transfusions from the donor of its allograft. All dogs were given azathioprine and prednisone postoperatively for immunosuppression. Four of 6 dogs given pretransplantation transfusions were healthy 1 year after surgical manipulation was done, and 2 died for reasons other than graft rejection. Of the 6 dogs that were not given pretransplantation transfusions, 3 were healthy after 1 years, but 2 were euthanatized because of graft rejection, and the last was euthanatized because of both graft rejection and intussusception. Other complications in these dogs were leukopenia (7 dogs), interdigital abscesses (2 dogs), urinary infection (3 dogs), and renal vein thrombosis (1 dog). Considering the lack of alternative methods for effective therapy for chronic renal failure in dogs, results of this study seem encouraging for selective use of renal transplantation, clinically. This study supports previous reports which indicated that pretransplantation transfusion enhanced graft survival in dogs.
在6对同窝小猎犬中，每对之间交换1个肾脏，并对另一侧肾脏进行切除。在此之前，每对中的一只狗接受了来自其同种异体移植供体的输血。所有狗术后均接受硫唑嘌呤和泼尼松进行免疫抑制治疗。在接受移植前输血的6只狗中，4只在手术操作完成1年后健康存活，2只因移植排斥以外的原因死亡。在未接受移植前输血的6只狗中，3只在1年后健康存活，但2只因移植排斥而实施安乐死，最后1只因移植排斥和肠套叠而实施安乐死。这些狗的其他并发症包括白细胞减少症（7只）、指间脓肿（2只）、泌尿系统感染（3只）和肾静脉血栓形成（1只）。考虑到犬慢性肾衰竭缺乏有效的替代治疗方法，该研究结果对于临床选择性使用肾移植似乎是令人鼓舞的。这项研究支持了先前的报告，这些报告表明移植前输血可提高犬的移植物存活率。
