Directorate General for Disease Surveillance and Control, Muscat, Oman.
Int J STD AIDS. 2021 Mar;32(3):239-245. doi: 10.1177/0956462420956850. Epub 2020 Dec 18.
We conducted a cross-sectional analysis to determine HIV virologic failure and its associated factors among Omani people living with HIV who are on ART for > 6 months. Patients (n = 1427) were identified from a central national HIV surveillance dataset. Two-thirds (67%) of patients were male, and the median age was 39 years (IQR, 32-48 years). Out of 1427 patients, 14.4% had virologic failure (HIV viral load [VL] ≥ 200 copies/ml). The multivariate analysis showed that patients aged 25-49 years (adjusted odds ratio [aOR]: 1.76, 95% CI: 1.01-3.08) were significantly more likely to fail treatment, compared to those aged ≥ 50 years. Besides, having "Other" HIV risk factor (compared to heterosexuals, aOR: 1.82, 95% CI: 1.02-3.24) and receiving HIV care outside the capital Muscat (compared to those cared for in Muscat, aOR: 1.73, 95% CI: 1.11-2.7) were independently associated with virologic failure. HIV viral suppression (85.6%) in Oman is encouraging; however, further strategies, mainly targeting patients who are young (<50 years), those not disclosing their HIV risk factor and those attending HIV treatment centres outside Muscat, are required to enhance HIV treatment outcome in Oman.
我们进行了一项横断面分析，以确定在接受抗逆转录病毒疗法（ART）治疗 > 6 个月的阿曼艾滋病毒感染者中病毒学失败及其相关因素。患者（n = 1427）从国家艾滋病毒监测的中央数据集确定。三分之二（67%）的患者为男性，中位年龄为 39 岁（IQR，32-48 岁）。在 1427 名患者中，有 14.4%发生病毒学失败（HIV 病毒载量[VL]≥200 拷贝/ml）。多变量分析显示，与≥50 岁的患者相比，25-49 岁的患者（调整后的优势比[aOR]：1.76，95%CI：1.01-3.08）更有可能治疗失败。此外，与异性恋者相比，有“其他”艾滋病毒风险因素（aOR：1.82，95%CI：1.02-3.24）和在首都马斯喀特以外接受艾滋病毒护理（与在马斯喀特接受护理的患者相比，aOR：1.73，95%CI：1.11-2.7）与病毒学失败独立相关。阿曼的 HIV 病毒抑制率（85.6%）令人鼓舞；然而，需要进一步的策略，主要针对年轻（<50 岁）的患者、那些不披露其艾滋病毒风险因素的患者和在马斯喀特以外的艾滋病毒治疗中心就诊的患者，以提高阿曼的艾滋病毒治疗结果。
