Department of Biomedical Informatics and Medical Statistics, Medical Research Institute, Alexandria University, 21561 Alexandria, Egypt.
Tropical Health Department, High Institute of Public Health, Alexandria University, 21561 Alexandria, Egypt.
Ann Glob Health. 2024 Sep 16;90(1):58. doi: 10.5334/aogh.4491. eCollection 2024.
Adherence to medications is a crucial factor in achieving the best therapeutic outcomes for patients who have human immunodeficiency virus (HIV). Little is known about the rate and predictors of adherence to antiretroviral therapy (ART) in Egypt. To assess the degree of adherence to ART among people living with HIV/AIDS (PLWHA) in Egypt and to explore the predictors of non-adherence. A cross-sectional study was conducted from January 2021 to December 2021 on 785 PLWHA attending an ART clinic at the main fever hospital in Alexandria, Egypt. Data collection was done using an interviewing questionnaire and pharmacy database records. Multivariate logistic regression analysis was done to identify the predictors of adherence to ART. The overall adherence rate to ART among the study subjects was 66.7%. Female sex (Adjusted Odds Ratio [95% CI]: 1.73 [1.01-2.96]), intravenous drug use (AOR [95% CI]: 2.87 [1.27-6.49]), fair satisfaction with the health service at ART clinics (OR [95% CI]: 1.86 [1.27-2.73]) appeared as independent predictors of poor adherence. The degree of adherence to ART among PLWHA in Egypt is noticeably high, although it was influenced by several patient-, healthcare-, and community-related factors. This work provides an accurate, standardized tool to measure adherence and identify factors that contribute to non-adherence.
在接受人类免疫缺陷病毒 (HIV) 治疗的患者中，坚持用药是获得最佳治疗效果的关键因素。目前，埃及患者对接受抗逆转录病毒治疗 (ART) 的坚持率及其影响因素知之甚少。本研究旨在评估埃及艾滋病毒/艾滋病 (PLWHA) 人群对 ART 的坚持程度，并探讨不坚持治疗的预测因素。这是一项横断面研究，于 2021 年 1 月至 12 月在埃及亚历山大主要发热医院的一个 ART 诊所对 785 名 PLWHA 进行。采用访谈问卷和药房数据库记录收集数据。采用多变量逻辑回归分析确定坚持 ART 的预测因素。研究对象对 ART 的总体坚持率为 66.7%。女性（调整优势比 [95%CI]：1.73 [1.01-2.96]）、静脉吸毒（调整优势比 [95%CI]：2.87 [1.27-6.49]）、对 ART 诊所的卫生服务满意度一般（比值比 [95%CI]：1.86 [1.27-2.73]）是坚持治疗较差的独立预测因素。尽管埃及 PLWHA 对 ART 的坚持程度明显较高，但这受到患者、医疗保健和社区相关因素的影响。本研究提供了一种准确、标准化的工具来衡量坚持度，并确定导致不坚持治疗的因素。
