恢复抗体相关的迟发性无视网膜病性共济失调。
Recoverin antibody-associated late-onset ataxia without retinopathy.
机构信息
Department of Neurology, Universitätsklinikum Schleswig-Holstein Campus Lübeck Klinik für Neurologie, Lubeck, Schleswig-Holstein, Germany
Institute of Systems Motor Science, Universität zu Lübeck, Lubeck, Schleswig-Holstein, Germany.
出版信息
BMJ Case Rep. 2020 Dec 17;13(12):e237479. doi: 10.1136/bcr-2020-237479.
Abstract
Acquired cerebellar ataxia is a rare, in many cases immune-modulated and paraneoplastic illness. Acute and slowly progredient processes are possible. An early treatment is important for a good clinical outcome. Here we present the case of female patient in her 60s with an antirecoverin associated cerebellitis without retinopathia and neoplasia. After an immunosuppressive therapy with steroids and rituximab the symptoms improved, and the progression could be stopped.
摘要
获得性小脑共济失调是一种罕见的疾病，在许多情况下与免疫调节和副肿瘤有关。可能会出现急性和缓慢进展的过程。早期治疗对于良好的临床预后非常重要。在此，我们报告了一例 60 多岁的女性患者，患有抗富亮氨酸胶质瘤失活 1 蛋白相关小脑炎，无视网膜病和肿瘤。经类固醇和利妥昔单抗免疫抑制治疗后，症状改善，病情进展得到控制。
相似文献
1
Recoverin antibody-associated late-onset ataxia without retinopathy.恢复抗体相关的迟发性无视网膜病性共济失调。
BMJ Case Rep. 2020 Dec 17;13(12):e237479. doi: 10.1136/bcr-2020-237479.
2
Intravenous immunoglobulin and rituximab for cerebellar ataxia with glutamic acid decarboxylase autoantibodies.静脉注射免疫球蛋白和利妥昔单抗治疗谷氨酸脱羧酶自身抗体相关小脑性共济失调。
Cerebellum. 2014 Jun;13(3):318-22. doi: 10.1007/s12311-013-0534-3.
3
Case of anti-Zic4 antibody-mediated cerebellar toxicity induced by dual checkpoint inhibition in head and neck squamous cell carcinoma.头颈部鳞状细胞癌中双重检查点抑制引起的抗 Zic4 抗体介导的小脑毒性病例。
BMJ Case Rep. 2020 Sep 17;13(9):e235607. doi: 10.1136/bcr-2020-235607.
4
Favorable Outcomes in a Case of Non-paraneoplastic DNER Ataxia Treated with Immunotherapy.免疫治疗治疗非副肿瘤性 DNER 共济失调病例的良好结果。
Cerebellum. 2024 Aug;23(4):1697-1701. doi: 10.1007/s12311-023-01636-z. Epub 2023 Nov 22.
5
A Case of Treatment Resistance and Complications in a Patient with Stiff Person Syndrome and Cerebellar Ataxia.1例僵人综合征合并小脑共济失调患者的治疗抵抗及并发症
Tremor Other Hyperkinet Mov (N Y). 2019 Oct 1;9. doi: 10.7916/tohm.v0.677. eCollection 2019.
6
Long-term clinical follow-up of a patient with non-paraneoplastic cerebellar ataxia associated with anti-mGluR1 autoantibodies.抗 mGluR1 自身抗体相关非副肿瘤性小脑共济失调患者的长期临床随访。
J Neuroimmunol. 2018 Jun 15;319:63-67. doi: 10.1016/j.jneuroim.2018.04.001. Epub 2018 Apr 4.
7
Clinical characteristics of patients with cerebellar ataxia associated with anti-GAD antibodies.抗谷氨酸脱羧酶抗体相关小脑性共济失调患者的临床特征
Arq Neuropsiquiatr. 2017 Mar;75(3):142-146. doi: 10.1590/0004-282X20170011.
8
[A case considered gluten ataxia with anti-TG6 IgA antibodies].一例被认为是伴有抗TG6 IgA抗体的麸质共济失调病例
Rinsho Shinkeigaku. 2016 Jun 22;56(6):413-7. doi: 10.5692/clinicalneurol.cn-000817. Epub 2016 May 21.
9
Non-paraneoplastic voltage-gated calcium channels antibody-mediated cerebellar ataxia responsive to IVIG treatment.非副肿瘤性电压门控钙通道抗体介导的小脑共济失调对静脉注射免疫球蛋白治疗有反应。
J Neurol Sci. 2014 Jan 15;336(1-2):169-70. doi: 10.1016/j.jns.2013.10.031. Epub 2013 Oct 29.
10
Acute Cerebellitis or Postinfectious Cerebellar Ataxia? Clinical and Imaging Features in Acute Cerebellitis.急性小脑炎还是感染后脑小脑共济失调？急性小脑炎的临床和影像特征。
J Child Neurol. 2020 May;35(6):380-388. doi: 10.1177/0883073820901407. Epub 2020 Mar 12.
引用本文的文献
1
Longitudinal Extensive Transverse Myelitis After Respiratory Syncytial Virus Vaccination With Positive Anti-Recoverin Antibodies.接种呼吸道合胞病毒疫苗后出现伴有抗恢复蛋白抗体阳性的纵向广泛横贯性脊髓炎。
Case Rep Neurol Med. 2025 Aug 30;2025:6597450. doi: 10.1155/crnm/6597450. eCollection 2025.
2
Social anxiety disorder and antibodies against glial cells in the cerebrospinal fluid.社交焦虑障碍与脑脊液中抗神经胶质细胞抗体
Brain Behav Immun Health. 2025 Jul 19;48:101064. doi: 10.1016/j.bbih.2025.101064. eCollection 2025 Oct.
3
Case report: A case of anti-recoverin antibody-positive encephalitis exhibiting Cotard and Capgras delusions that was successfully treated with electroconvulsive therapy.病例报告：一例抗恢复蛋白抗体阳性脑炎患者出现科塔尔和卡普格拉妄想，经电休克治疗成功治愈。
Front Psychiatry. 2024 Jan 25;15:1330745. doi: 10.3389/fpsyt.2024.1330745. eCollection 2024.
4
Dysfunctional Learning and Verbal Memory in Patients with Elevated Tau Protein Levels and Serum Recoverin Autoantibodies-Case Series and Review.血清恢复蛋白自身抗体及 Tau 蛋白水平升高患者的学习功能障碍与言语记忆——病例系列及综述
Brain Sci. 2021 Dec 23;12(1):15. doi: 10.3390/brainsci12010015.
5
Autoimmune basal ganglia encephalitis associated with anti-recoverin antibodies: A case report.与抗恢复蛋白抗体相关的自身免疫性基底节脑炎：一例报告。
eNeurologicalSci. 2021 Nov 24;25:100382. doi: 10.1016/j.ensci.2021.100382. eCollection 2021 Dec.
本文引用的文献
1
Immune-mediated Cerebellar Ataxias: Practical Guidelines and Therapeutic Challenges.免疫介导的小脑共济失调：实用指南与治疗挑战。
Curr Neuropharmacol. 2019;17(1):33-58. doi: 10.2174/1570159X16666180917105033.
2
Immune-mediated ataxias.免疫介导性共济失调
Handb Clin Neurol. 2018;155:313-332. doi: 10.1016/B978-0-444-64189-2.00021-4.
3
Autoimmune retinopathy: A Review.自身免疫性视网膜病变：综述
Int J Retina Vitreous. 2018 Jan 3;4:1. doi: 10.1186/s40942-017-0104-9. eCollection 2018.
4
Consensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias.共识文件：小脑共济失调的神经免疫机制
Cerebellum. 2016 Apr;15(2):213-32. doi: 10.1007/s12311-015-0664-x.
5
Immune-mediated acquired ataxias.免疫介导的获得性共济失调
Handb Clin Neurol. 2012;103:189-99. doi: 10.1016/B978-0-444-51892-7.00011-5.
6
[Paraneoplastic retinopathy and optic neuropathy].[副肿瘤性视网膜病变和视神经病变]
Brain Nerve. 2010 Apr;62(4):371-6.
7
Cerebellar ataxia as a possible organ-specific autoimmune disease.小脑性共济失调作为一种可能的器官特异性自身免疫性疾病。
Mov Disord. 2008 Jul 30;23(10):1370-7. doi: 10.1002/mds.22129.
8
Isolation and characterization of recoverin-like Ca(2+)-binding protein from rat brain.从大鼠脑中分离和鉴定类恢复蛋白的钙离子结合蛋白
Biochem Biophys Res Commun. 1992 Feb 28;183(1):245-51. doi: 10.1016/0006-291x(92)91635-4.
9
Identification of recoverin-like immunoreactivity in mouse brain.小鼠脑中恢复蛋白样免疫反应性的鉴定。
Brain Res. 1992 Feb 7;571(2):350-3. doi: 10.1016/0006-8993(92)90676-z.
Zotero 插件