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火星用于核医学、分子成像和分子靶向放射性药物治疗。

Mars Shot for Nuclear Medicine, Molecular Imaging, and Molecularly Targeted Radiopharmaceutical Therapy.

机构信息

Mallinckrodt Institute of Radiology, Washington University St. Louis, Missouri.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.

出版信息

J Nucl Med. 2021 Jan;62(1):6-14. doi: 10.2967/jnumed.120.253450.

DOI:10.2967/jnumed.120.253450
PMID:33334911
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9364879/
Abstract

The Society of Nuclear Medicine and Molecular Imaging created the Value Initiative in 2017 as a major component of its strategic plan to further demonstrate the value of molecular imaging and molecularly targeted radiopharmaceutical therapy to patients, physicians, payers, and funding agencies. The research and discovery domain, 1 of 5 under the Value Initiative, has a goal of advancing the research and development of diagnostic and therapeutic nuclear medicine. Research and discovery efforts and achievements are essential to ensure a bright future for NM and to translate science to practice. Given the remarkable progress in the field, leaders from the research and discovery domain and society councils identified 5 broad areas of opportunity with potential for substantive growth and clinical impact. This article discusses these 5 growth areas, identifying specific areas of particularly high importance for future study and development. As there was an understanding that goals should be both visionary yet achievable, this effort was called the Mars shot for nuclear medicine.

摘要

核医学与分子影像学会于 2017 年成立了价值倡议,作为其战略计划的重要组成部分,旨在进一步向患者、医生、支付方和资助机构展示分子影像和分子靶向放射性药物治疗的价值。该倡议下的五个领域之一的研究与发现领域,旨在推进诊断和治疗核医学的研究与开发。研究与发现工作和成果对于确保核医学的光明未来以及将科学转化为实践至关重要。鉴于该领域的显著进展,研究与发现领域和学会理事会的领导者确定了 5 个具有潜在重大增长和临床影响的广泛机会领域。本文讨论了这 5 个增长领域,并确定了未来研究和发展特别重要的具体领域。由于人们明白目标应该既具有远见又可实现,因此这项工作被称为核医学的“火星计划”。

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1
Reinventing Molecular Imaging with Total-Body PET, Part I: Technical Revolution in Evolution.全身 PET 重铸分子影像学:第一部分:技术演进中的革命。
PET Clin. 2020 Oct;15(4):427-438. doi: 10.1016/j.cpet.2020.06.012. Epub 2020 Aug 11.
2
Prospective Evaluation of F-DCFPyL PET/CT in Detection of High-Risk Localized Prostate Cancer: Comparison With mpMRI.前瞻性评估 F-DCFPyL PET/CT 在检测高危局限性前列腺癌中的作用:与 mpMRI 的比较。
AJR Am J Roentgenol. 2020 Sep;215(3):652-659. doi: 10.2214/AJR.19.22042. Epub 2020 Jul 8.
3
Head-to-Head Evaluation of F-FES and F-FDG PET/CT in Metastatic Invasive Lobular Breast Cancer.头对头评估 F-FES 和 F-FDG PET/CT 在转移性浸润性小叶乳腺癌中的应用。
J Nucl Med. 2021 Mar;62(3):326-331. doi: 10.2967/jnumed.120.247882. Epub 2020 Jul 17.
4
Evaluating Biochemically Recurrent Prostate Cancer: Histologic Validation of F-DCFPyL PET/CT with Comparison to Multiparametric MRI.评估生化复发前列腺癌:F-DCFPyL PET/CT 与多参数 MRI 的组织学验证比较。
Radiology. 2020 Sep;296(3):564-572. doi: 10.1148/radiol.2020192018. Epub 2020 Jul 7.
5
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Radiology. 2020 Aug;296(2):370-378. doi: 10.1148/radiol.2020192828. Epub 2020 Jun 9.
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Radiology. 2020 Jul;296(1):44-55. doi: 10.1148/radiol.2020191689. Epub 2020 May 12.
9
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Oncologist. 2020 Oct;25(10):835-844. doi: 10.1634/theoncologist.2019-0967. Epub 2020 May 15.
10
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