The University of Waikato, Hamilton, 3240, New Zealand.
Sci Rep. 2020 Dec 17;10(1):22201. doi: 10.1038/s41598-020-79192-3.
Prosthesis bacterial infection occurring during surgery is a rising health issue. Pathogenic bacterial infection causes inflammation, interferes with the healing process, inhibits osteogenesis and, eventually, leads to implant failure. These issues can be tackled either by applying coatings or developing multifunctional (i.e. structural and antibacterial) materials. In this work, β eutectoid bearing functionalised Ti alloys were designed and manufactured via the cost-effective press and sinter powder metallurgy route. The systematic analysis of the ternary Ti-xCu-yMn alloys shows that the mechanical properties proportionally increase with the amount of alloying elements added. All the ternary Ti-xCu-yMn alloys have strong antibacterial activity against Escherichia coli with respect to the negative control (i.e. pure Ti). Our study demonstrates that ternary Ti-xCu-yMn alloys are promising candidates for structural prostheses functionalised with antibacterial capability.
手术过程中假体细菌感染是一个日益严重的健康问题。致病菌感染会引起炎症，干扰愈合过程，抑制成骨作用，最终导致植入物失效。这些问题可以通过涂层处理或开发多功能（即结构和抗菌）材料来解决。在这项工作中，通过具有成本效益的压制和烧结粉末冶金工艺设计和制造了含β共析的功能性 Ti 合金。对三元 Ti-xCu-yMn 合金的系统分析表明，机械性能与添加的合金元素成正比增加。与阴性对照（即纯 Ti）相比，所有三元 Ti-xCu-yMn 合金对大肠杆菌均具有很强的抗菌活性。我们的研究表明，三元 Ti-xCu-yMn 合金是具有抗菌功能的结构假体的有前途的候选材料。
