• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

增强型巨噬细胞介导的卵黄脂质递药系统对乳腺癌的抗肿瘤疗效。

Enhanced Antitumor Efficacy of Macrophage-Mediated Egg Yolk Lipid-Derived Delivery System Against Breast Cancer.

机构信息

Department of Clinical Medical Laboratory, Huai'an Maternity and Child Healthcare Hospital Affiliated to Yangzhou University Medical Academy, Huai'an 223002, People's Republic of China.

Department of Central Laboratory, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an 223300, People's Republic of China.

出版信息

Int J Nanomedicine. 2020 Dec 10;15:10075-10084. doi: 10.2147/IJN.S271310. eCollection 2020.

DOI:10.2147/IJN.S271310
PMID:33335395
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7736838/
Abstract

BACKGROUND

Chemotherapy is the primary treatment for most cancers apart from surgery. However, the use of chemotherapeutic drugs is limited by side effects and restricted accumulation in tumors because of unique tumor microenvironments. Macrophages have excellent drug delivery potential owing to their chemotaxis and can home in on tumors.

MATERIALS AND METHODS

We developed an effective drug-delivery system for doxorubicin using macrophages. Doxorubicin-loaded egg yolk lipid-derived nanovectors (EYLNs-Dox) were prepared, EYLNs-Dox-loaded macrophages (Mac/EYLNs-Dox) were developed and their tumor penetration and anti-cancer activity against 4T1 cells were analyzed. The biodistribution and anti-4T1 breast cancer activities were determined using 4T1 subcutaneous and lung metastasis models.

RESULTS

EYLNs-Dox was successfully internalized into macrophages without affecting their viability and was less toxic than Dox. Mac/EYLNs-Dox penetrated the 4T1 tumor spheroids more efficiently and was more effective in inhibiting tumors in vitro. Macrophages significantly enhanced the distribution of EYLNs vectors in both inflammatory and tumor sites, playing a more effective role in the inhibition of tumors.

CONCLUSION

EYLNs-Dox can be effectively delivered using macrophages and Mac/EYLNs-Dox might be a promising targeted delivery system for breast cancer.

摘要

背景

化疗是大多数癌症除手术外的主要治疗方法。然而，由于独特的肿瘤微环境，化疗药物的应用受到副作用和在肿瘤中积累受限的限制。巨噬细胞具有出色的药物输送潜力，因为它们具有趋化性，可以归巢到肿瘤部位。

材料与方法

我们使用巨噬细胞开发了一种有效的阿霉素药物输送系统。制备了载阿霉素的卵黄脂质衍生纳米载体（EYLNs-Dox），开发了载阿霉素的巨噬细胞（Mac/EYLNs-Dox），并分析了它们对 4T1 细胞的肿瘤穿透和抗癌活性。使用 4T1 皮下和肺转移模型确定了生物分布和抗 4T1 乳腺癌活性。

结果

EYLNs-Dox 成功地被巨噬细胞内化，而不影响其活力，并且比阿霉素的毒性更小。Mac/EYLNs-Dox 更有效地穿透 4T1 肿瘤球体，并在体外更有效地抑制肿瘤。巨噬细胞显著增加了 EYLNs 载体在炎症和肿瘤部位的分布，在抑制肿瘤方面发挥了更有效的作用。

结论

可以使用巨噬细胞有效地输送 EYLNs-Dox，Mac/EYLNs-Dox 可能是一种有前途的乳腺癌靶向输送系统。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9468/7736838/7fac3e079e69/IJN-15-10075-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9468/7736838/5659ab85c140/IJN-15-10075-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9468/7736838/f326076a6045/IJN-15-10075-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9468/7736838/f588c505db43/IJN-15-10075-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9468/7736838/6e01cebfdc43/IJN-15-10075-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9468/7736838/7fac3e079e69/IJN-15-10075-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9468/7736838/5659ab85c140/IJN-15-10075-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9468/7736838/f326076a6045/IJN-15-10075-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9468/7736838/f588c505db43/IJN-15-10075-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9468/7736838/6e01cebfdc43/IJN-15-10075-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9468/7736838/7fac3e079e69/IJN-15-10075-g0005.jpg

相似文献

1
Enhanced Antitumor Efficacy of Macrophage-Mediated Egg Yolk Lipid-Derived Delivery System Against Breast Cancer.增强型巨噬细胞介导的卵黄脂质递药系统对乳腺癌的抗肿瘤疗效。
Int J Nanomedicine. 2020 Dec 10;15:10075-10084. doi: 10.2147/IJN.S271310. eCollection 2020.
2
Nanovector Assembled from Natural Egg Yolk Lipids for Tumor-Targeted Delivery of Therapeutics.由天然蛋黄脂质组装的纳米载体用于治疗药物的肿瘤靶向递送。
ACS Appl Mater Interfaces. 2020 Feb 19;12(7):7984-7994. doi: 10.1021/acsami.9b22293. Epub 2020 Feb 5.
3
α- Tocopherol succinate loaded nano-structed lipid carriers improves antitumor activity of doxorubicin in breast cancer models in vivo.α-生育酚琥珀酸酯负载的纳米结构脂质载体提高了阿霉素在体内乳腺癌模型中的抗肿瘤活性。
Biomed Pharmacother. 2018 Jul;103:1348-1354. doi: 10.1016/j.biopha.2018.04.139. Epub 2018 May 7.
4
Leukocyte-Mediated Combined Targeted Chemo and Gene Therapy for Esophageal Cancer.白细胞介介导的联合靶向化疗和基因治疗食管癌。
ACS Appl Mater Interfaces. 2020 Oct 21;12(42):47330-47341. doi: 10.1021/acsami.0c15419. Epub 2020 Sep 30.
5
Co-delivery of doxorubicin, docosahexaenoic acid, and α-tocopherol succinate by nanostructured lipid carriers has a synergistic effect to enhance antitumor activity and reduce toxicity.载多柔比星、二十二碳六烯酸和α-生育酚琥珀酸酯的纳米结构脂质载体的共递送具有协同作用，可增强抗肿瘤活性并降低毒性。
Biomed Pharmacother. 2020 Dec;132:110876. doi: 10.1016/j.biopha.2020.110876. Epub 2020 Oct 28.
6
Tumor Microenvironment-Triggered Charge Reversal Polymetformin-Based Nanosystem Co-Delivered Doxorubicin and IL-12 Cytokine Gene for Chemo-Gene Combination Therapy on Metastatic Breast Cancer.肿瘤微环境触发的电荷反转基于聚二甲双胍的纳米系统共递送多柔比星和白细胞介素-12 细胞因子基因用于转移性乳腺癌的化疗-基因联合治疗。
ACS Appl Mater Interfaces. 2020 Oct 14;12(41):45873-45890. doi: 10.1021/acsami.0c14405. Epub 2020 Sep 29.
7
Co-delivery of cisplatin and doxorubicin by covalently conjugating with polyamidoamine dendrimer for enhanced synergistic cancer therapy.通过与聚酰胺-胺树枝状聚合物共价结合来共递送顺铂和阿霉素，以增强协同癌症治疗。
Acta Biomater. 2019 Jan 15;84:367-377. doi: 10.1016/j.actbio.2018.12.007. Epub 2018 Dec 5.
8
Enhanced 4T1 breast carcinoma anticancer activity by co-delivery of doxorubicin and curcumin with core-shell drug-carrier based on heparin modified poly(L-lactide) grafted polyethylenimine cationic nanoparticles.基于肝素修饰聚 L-乳酸接枝聚乙烯亚胺的核壳型载药纳米粒子共载多柔比星和姜黄素增强 4T1 乳腺癌抗癌活性。
J Biomed Nanotechnol. 2014 Feb;10(2):227-37. doi: 10.1166/jbn.2014.1785.
9
Cell-penetrating corosolic acid liposome as a functional carrier for delivering chemotherapeutic drugs.细胞穿透性熊果酸脂质体作为一种功能性载体，用于递送达卡巴他赛等化疗药物。
Acta Biomater. 2020 Apr 1;106:301-313. doi: 10.1016/j.actbio.2020.02.013. Epub 2020 Feb 17.
10
A Novel AS1411 Aptamer-Based Three-Way Junction Pocket DNA Nanostructure Loaded with Doxorubicin for Targeting Cancer Cells in Vitro and in Vivo.基于新型 AS1411 适体的三链结口袋 DNA 纳米结构载多柔比星用于体外和体内靶向癌细胞。
Mol Pharm. 2018 May 7;15(5):1972-1978. doi: 10.1021/acs.molpharmaceut.8b00124. Epub 2018 Apr 23.

引用本文的文献

1
Biomimetic Systems Involving Macrophages and Their Potential for Targeted Drug Delivery.涉及巨噬细胞的仿生系统及其在靶向药物递送方面的潜力。
Biomimetics (Basel). 2023 Nov 12;8(7):543. doi: 10.3390/biomimetics8070543.
2
Cell-nanocarrier drug delivery system: a promising strategy for cancer therapy.细胞-纳米载体药物传递系统：癌症治疗的一种有前途的策略。
Drug Deliv Transl Res. 2024 Mar;14(3):581-596. doi: 10.1007/s13346-023-01429-1. Epub 2023 Sep 18.
3
Cell-based carrier for targeted hitchhiking delivery.基于细胞的载体用于靶向搭便车传递。

本文引用的文献

1
Phagocyte-membrane-coated and laser-responsive nanoparticles control primary and metastatic cancer by inducing anti-tumor immunity.吞噬细胞膜包被且具有激光响应性的纳米颗粒通过诱导抗肿瘤免疫来控制原发性和转移性癌症。
Biomaterials. 2020 Oct;255:120159. doi: 10.1016/j.biomaterials.2020.120159. Epub 2020 Jun 7.
2
Macrophage-mimic shape changeable nanomedicine retained in tumor for multimodal therapy of breast cancer.模拟巨噬细胞形态变化的纳米医学在肿瘤中滞留用于乳腺癌的多模式治疗。
J Control Release. 2020 May 10;321:589-601. doi: 10.1016/j.jconrel.2020.02.043. Epub 2020 Feb 28.
3
Nanovector Assembled from Natural Egg Yolk Lipids for Tumor-Targeted Delivery of Therapeutics.
Drug Deliv Transl Res. 2022 Nov;12(11):2634-2648. doi: 10.1007/s13346-022-01149-y. Epub 2022 May 2.
由天然蛋黄脂质组装的纳米载体用于治疗药物的肿瘤靶向递送。
ACS Appl Mater Interfaces. 2020 Feb 19;12(7):7984-7994. doi: 10.1021/acsami.9b22293. Epub 2020 Feb 5.
4
Advances in Toxicological Research of the Anticancer Drug Cisplatin.顺铂抗癌药物毒理学研究进展。
Chem Res Toxicol. 2019 Aug 19;32(8):1469-1486. doi: 10.1021/acs.chemrestox.9b00204. Epub 2019 Aug 5.
5
A novel macrophage-mediated biomimetic delivery system with NIR-triggered release for prostate cancer therapy.一种新型巨噬细胞介导的仿生递药系统，具有近红外触发释放功能，可用于前列腺癌治疗。
J Nanobiotechnology. 2019 Jul 10;17(1):83. doi: 10.1186/s12951-019-0513-z.
6
Monocytes as Carriers of Magnetic Nanoparticles for Tracking Inflammation in the Epileptic Rat Brain.单核细胞作为载磁纳米粒子在癫痫大鼠脑炎症示踪中的应用。
Curr Drug Deliv. 2019;16(7):637-644. doi: 10.2174/1567201816666190619122456.
7
Employment of enhanced permeability and retention effect (EPR): Nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer.增强型渗透和保留效应（EPR）的应用：基于纳米颗粒的精准工具，用于靶向治疗和诊断剂在癌症中的应用。
Mater Sci Eng C Mater Biol Appl. 2019 May;98:1252-1276. doi: 10.1016/j.msec.2019.01.066. Epub 2019 Jan 18.
8
Inhibition of cyclin-dependent kinase 2 protects against doxorubicin-induced cardiomyocyte apoptosis and cardiomyopathy.抑制细胞周期蛋白依赖性激酶 2 可预防阿霉素诱导的心肌细胞凋亡和心肌病。
J Biol Chem. 2018 Dec 21;293(51):19672-19685. doi: 10.1074/jbc.RA118.004673. Epub 2018 Oct 25.
9
Remote-Loaded Platelet Vesicles for Disease-Targeted Delivery of Therapeutics.用于疾病靶向递送治疗药物的远程加载血小板囊泡
Adv Funct Mater. 2018 May 30;28(22). doi: 10.1002/adfm.201801032. Epub 2018 Apr 19.
10
Nano based drug delivery systems: recent developments and future prospects.基于纳米的药物传递系统：最新进展与未来展望。
J Nanobiotechnology. 2018 Sep 19;16(1):71. doi: 10.1186/s12951-018-0392-8.