National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Palaj, Opposite Air Force Station, Gandhinagar, Gujarat 382355, India.
National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Palaj, Opposite Air Force Station, Gandhinagar, Gujarat 382355, India.
Mater Sci Eng C Mater Biol Appl. 2019 May;98:1252-1276. doi: 10.1016/j.msec.2019.01.066. Epub 2019 Jan 18.
In tumorous tissues, the absence of vasculature supportive tissues intimates the formation of leaky vessels and pores (100 nm to 2 μm in diameter) and the poor lymphatic system offers great opportunity to treat cancer and the phenomenon is known as Enhanced permeability and retention (EPR) effect. The trends in treating cancer by making use of EPR effect is increasing day by day and generate multitudes of possibility to design novel anticancer therapeutics. This review aimed to present various factors affecting the EPR effect along with important things to know about EPR effect such as tumor perfusion, lymphatic function, interstitial penetration, vascular permeability, nanoparticle retention etc. This manuscript expounds the current advances and cross-talks the developments made in the of EPR effect-based therapeutics in cancer therapy along with a transactional view of its current clinical and industrial aspects.
在肿瘤组织中，缺乏支持性的脉管组织提示形成渗漏性血管和孔隙（直径 100nm 至 2μm），而不良的淋巴系统为治疗癌症提供了很好的机会，这种现象被称为增强的通透性和保留（EPR）效应。利用 EPR 效应治疗癌症的趋势日益增加，为设计新型抗癌治疗方法提供了无数可能性。本综述旨在介绍影响 EPR 效应的各种因素，以及关于 EPR 效应的一些重要知识，如肿瘤灌注、淋巴功能、间质渗透、血管通透性、纳米颗粒保留等。本文阐述了当前的进展，并交流了基于 EPR 效应的治疗在癌症治疗中的发展，以及其当前临床和工业方面的转化观点。
