Novel CDK2 Inhibitors for Treating Cancer.
作者信息
Sabnis Ram W
机构信息
Smith, Gambrell & Russell LLP, 1230 Peachtree Street NE, Suite 3100, Atlanta, Georgia 30309, United States.
出版信息
ACS Med Chem Lett. 2020 Oct 1;11(12):2346-2347. doi: 10.1021/acsmedchemlett.0c00500. eCollection 2020 Dec 10.
Abstract
摘要
相似文献
1
Novel CDK2 Inhibitors for Treating Cancer.用于治疗癌症的新型CDK2抑制剂
ACS Med Chem Lett. 2020 Oct 1;11(12):2346-2347. doi: 10.1021/acsmedchemlett.0c00500. eCollection 2020 Dec 10.
2
Molecular Modeling and Design Studies of Purine Derivatives as Novel CDK2 Inhibitors.嘌呤衍生物作为新型 CDK2 抑制剂的分子建模与设计研究。
Molecules. 2018 Nov 9;23(11):2924. doi: 10.3390/molecules23112924.
3
Resistance to CDK2 inhibitors is associated with selection of polyploid cells in CCNE1-amplified ovarian cancer.对 CDK2 抑制剂的耐药性与 CCNE1 扩增型卵巢癌中多倍体细胞的选择有关。
Clin Cancer Res. 2013 Nov 1;19(21):5960-71. doi: 10.1158/1078-0432.CCR-13-1337. Epub 2013 Sep 4.
4
Virtual Screening for Potential Allosteric Inhibitors of Cyclin-Dependent Kinase 2 from Traditional Chinese Medicine.基于中药的细胞周期蛋白依赖性激酶2潜在变构抑制剂的虚拟筛选
Molecules. 2016 Sep 21;21(9):1259. doi: 10.3390/molecules21091259.
5
Cyclin-dependent kinase-2 as a target for cancer therapy: progress in the development of CDK2 inhibitors as anti-cancer agents.细胞周期蛋白依赖性激酶2作为癌症治疗靶点：CDK2抑制剂作为抗癌药物的研发进展
Curr Med Chem. 2015;22(2):237-63. doi: 10.2174/0929867321666141106113633.
6
Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An Update.细胞周期蛋白依赖性激酶 2 抑制剂在癌症治疗中的应用：最新进展。
J Med Chem. 2019 May 9;62(9):4233-4251. doi: 10.1021/acs.jmedchem.8b01469. Epub 2018 Dec 20.
7
Design, synthesis, and molecular docking study of 3H-imidazole[4,5-c]pyridine derivatives as CDK2 inhibitors.设计、合成及 3H-咪唑并[4,5-c]吡啶衍生物作为 CDK2 抑制剂的分子对接研究。
Arch Pharm (Weinheim). 2018 Jun;351(6):e1700381. doi: 10.1002/ardp.201700381. Epub 2018 Apr 30.
8
Cyclin-Dependent Kinase 2 in Cellular Senescence and Cancer. A Structural and Functional Review.细胞衰老与癌症中的细胞周期蛋白依赖性激酶 2：结构与功能综述。
Curr Drug Targets. 2019;20(7):716-726. doi: 10.2174/1389450120666181204165344.
9
Fusion of Structure and Ligand Based Methods for Identification of Novel CDK2 Inhibitors.基于结构和配体方法融合用于鉴定新型CDK2抑制剂
J Chem Inf Model. 2017 Aug 28;57(8):1957-1969. doi: 10.1021/acs.jcim.7b00293. Epub 2017 Aug 3.
10
Design, synthesis and biological evaluation of pyrimidine derivatives as novel CDK2 inhibitors that induce apoptosis and cell cycle arrest in breast cancer cells.嘧啶衍生物的设计、合成及作为新型 CDK2 抑制剂的生物评价，该抑制剂能诱导乳腺癌细胞凋亡和细胞周期停滞。
Bioorg Med Chem. 2018 Jul 23;26(12):3491-3501. doi: 10.1016/j.bmc.2018.05.024. Epub 2018 May 17.
引用本文的文献
1
Searching potential GSK-3β inhibitors from marine sources using atomistic simulations.利用原子模拟从海洋资源中寻找潜在的糖原合成酶激酶-3β抑制剂。
Mol Divers. 2025 Apr 2. doi: 10.1007/s11030-025-11174-x.
2
Design and Synthesis of New 5-Methylisatin Derivatives as Potential CDK2 Inhibitors.新型5-甲基异吲哚酮衍生物作为潜在CDK2抑制剂的设计与合成
Int J Mol Sci. 2025 Feb 27;26(5):2144. doi: 10.3390/ijms26052144.
3
The anticancer potential of chemical constituents of Moringa oleifera targeting CDK-2 inhibition in estrogen receptor positive breast cancer using in-silico and in vitro approches.用计算机模拟和体外方法研究辣木化学成分对细胞周期蛋白依赖性激酶 2（CDK-2）的抑制作用及其在雌激素受体阳性乳腺癌中的抗癌潜力。
BMC Complement Med Ther. 2023 Nov 4;23(1):396. doi: 10.1186/s12906-023-04198-z.
4
Functional Genomic Analysis of CDK4 and CDK6 Gene Dependency across Human Cancer Cell Lines.功能基因组分析 CDK4 和 CDK6 基因在人类癌细胞系中的依赖性。
Cancer Res. 2022 Jun 6;82(11):2171-2184. doi: 10.1158/0008-5472.CAN-21-2428.
5
Targeting CDK4 and CDK6 in cancer.针对癌症中的 CDK4 和 CDK6。
Nat Rev Cancer. 2022 Jun;22(6):356-372. doi: 10.1038/s41568-022-00456-3. Epub 2022 Mar 18.
6
TANK-binding kinase 1 inhibitor GSK8612 enhances daunorubicin sensitivity in acute myeloid leukemia cells via the AKT-CDK2 pathway.TANK结合激酶1抑制剂GSK8612通过AKT-CDK2途径增强急性髓系白血病细胞对柔红霉素的敏感性。
Am J Transl Res. 2021 Dec 15;13(12):13640-13653. eCollection 2021.
本文引用的文献
1
A comprehensive insight on the recent development of Cyclic Dependent Kinase inhibitors as anticancer agents.关于环状依赖性激酶抑制剂作为抗癌药物的最新发展的全面见解。
Eur J Med Chem. 2020 Oct 1;203:112571. doi: 10.1016/j.ejmech.2020.112571. Epub 2020 Jul 15.
2
Cell cycle regulators in cancer cell metabolism.癌细胞代谢中的细胞周期调控因子。
Biochim Biophys Acta Mol Basis Dis. 2020 May 1;1866(5):165715. doi: 10.1016/j.bbadis.2020.165715. Epub 2020 Feb 5.
3
Targeting CDK2 in cancer: challenges and opportunities for therapy.针对癌症中的 CDK2：治疗的挑战与机遇。
Drug Discov Today. 2020 Feb;25(2):406-413. doi: 10.1016/j.drudis.2019.12.001. Epub 2019 Dec 10.
4
To control or to be controlled? Dual roles of CDK2 in DNA damage and DNA damage response.控制还是被控制？CDK2 在 DNA 损伤和 DNA 损伤反应中的双重作用。
DNA Repair (Amst). 2020 Jan;85:102702. doi: 10.1016/j.dnarep.2019.102702. Epub 2019 Sep 16.
Zotero 插件