Institute of Tropical Medicine, Antwerp, Antwerp, 2000, Belgium.
Medical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, Serekunda, The Gambia.
F1000Res. 2020 Jul 23;9:765. doi: 10.12688/f1000research.25227.2. eCollection 2020.
: This study aimed to summarise the evidence on the impact of routine administration of 10-valent and 13-valent pneumococcal conjugate vaccines on pneumonia in children under five years of age in sub-Saharan Africa. A systematic search of the literature was conducted including primary research reporting on the impact of 10- or 13-valent pneumococcal vaccines on childhood pneumonia in a sub-Saharan African country. Case-control, cohort, pre-post and time-series study designs were eligible for inclusion. Thematic narrative synthesis was carried out to summarise the findings. Eight records were included in the final analysis, 6 records were pre-post or time-series studies, 1 was a case-control study and 1 report combined pre-post and case-control studies. Vaccine impact on clinical pneumonia measured as percentage reduction in risk (%RR) was mostly non-significant. The reduction in risk was more consistent in radiological and pneumococcal pneumonia. Evidence of the positive impact of routine infant pneumococcal vaccination on clinical pneumonia incidence in sub-Saharan Africa is inconclusive. Ongoing surveillance and further research is required to establish the long term trend in pneumonia epidemiology and aetiology after PCV introduction. : CRD42019142369 30/09/19.
本研究旨在总结在撒哈拉以南非洲地区，常规使用 10 价和 13 价肺炎球菌结合疫苗对 5 岁以下儿童肺炎的影响的证据。系统检索文献，包括在撒哈拉以南非洲国家报告 10 价或 13 价肺炎球菌疫苗对儿童肺炎影响的原始研究。病例对照、队列、前后和时间序列研究设计符合纳入标准。采用主题叙述性综合方法总结研究结果。最终分析纳入 8 项记录，6 项为前后或时间序列研究，1 项为病例对照研究，1 项报告同时结合了前后和病例对照研究。疫苗对临床肺炎的影响（以风险降低百分比 [RRR] 衡量）大多不显著。在影像学和肺炎球菌肺炎中，风险降低更为一致。在撒哈拉以南非洲地区，常规婴儿肺炎球菌疫苗接种对临床肺炎发病率的积极影响的证据尚无定论。需要进行持续监测和进一步研究，以确定 PCV 引入后肺炎流行病学和病因学的长期趋势。
