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一项评估经颅直流电刺激背外侧前额叶皮层联合游戏平衡训练对老年人姿势平衡影响的对照、随机、盲法临床试验方案。

Protocol for a controlled, randomized, blind, clinical trial to assess the effects of anodal transcranial direct current stimulation dorsolateral prefrontal cortex associated with balance training using games in the postural balance of older people.

机构信息

Universidade Nove de Julho, Nove de Julho University, São Paulo, São Paulo, 01504-001, Brazil.

出版信息

F1000Res. 2020 Aug 21;9:1018. doi: 10.12688/f1000research.25164.2. eCollection 2020.

DOI:10.12688/f1000research.25164.2
PMID:33335715
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7713885/
Abstract

This study aims to evaluate the additional effect of anodal transcranial direct current stimulation (a-tDCS) applied on dorsolateral pré-frontal cortex on training postural balance with the use of video games in the aged. This is a blinded, randomized, controlled clinical trial protocol, with older people of both genders. Participants will be randomized into three training groups: Group 1 (videogame balance training), group 2 (videogame balance training associated with anodal tDCS), group 3 (videogame balance training associated with sham tDCS). The training will be carried out twice a week for four weeks, totaling eight sessions, and will be performed with the Nintendo Wii videogame console, using games that stimulate the postural balance associated with tDCS, with anode applied over the left dorsolateral prefrontal cortex and cathode on the contralateral supraorbital region at 2 mA for 20 minutes. The postural balance will be assessed using the Mini Test of the Balance Assessment System and posturography. Evaluations will be carried out before and after eight training sessions and 30 days after the end of treatment. Some studies show favorable results from the use of video games in improving postural balance in older people; however, their effect does not remain long-term. TDCS associated with other therapies can potentiate and prolong the effects of these therapies owing to its ability to stimulate neurotrophins important for neurogenesis, facilitating tasks that require attention, and helping to consolidate learning and memory. The effect of the two associated techniques on balance has not yet been tested in this population. Brazilian Registry of Clinical Trials ID U1111-1213-4266; registered on 15 October 2018.

摘要

本研究旨在评估经颅直流电刺激(transcranial direct current stimulation,tDCS)对老年人群使用视频游戏进行姿势平衡训练的额外效果。这是一项盲法、随机、对照临床试验方案,纳入了男女两性的老年人。参与者将随机分为三个训练组:组 1(视频游戏平衡训练)、组 2(视频游戏平衡训练联合阳极 tDCS)和组 3(视频游戏平衡训练联合假阳极 tDCS)。训练将每周进行两次,共进行四周,总计八次,使用任天堂 Wii 视频游戏控制台进行,游戏刺激与 tDCS 相关的姿势平衡,将阳极置于左侧背外侧前额叶皮质,阴极置于对侧眶上区,电流强度为 2 mA,持续 20 分钟。使用 Mini Test of the Balance Assessment System 和测姿仪评估姿势平衡。将在八次训练前后和治疗结束后 30 天进行评估。一些研究表明,视频游戏在改善老年人姿势平衡方面效果良好;然而,其效果并不持久。TDCS 与其他疗法联合使用可以增强和延长这些疗法的效果,因为它能够刺激对神经发生很重要的神经营养因子,促进需要注意力的任务,并有助于巩固学习和记忆。这两种联合技术对平衡的影响在该人群中尚未得到测试。巴西临床试验注册中心注册号 U1111-1213-4266;注册于 2018 年 10 月 15 日。

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