颈动脉病变中钙、水分含量与动脉粥样硬化病变超声表现之间的相关性。

Correlation between calcium, water contents and ultrasonographic appearance of atherosclerotic lesions of carotid artery lesions.

作者信息

Fülesdi Béla, Farkas Szabolcs, Gyöngyösi Zoltán, Siró Péter, Bereczki Dániel, Bacsó József, Csiba László

机构信息

Department of Anesthesiology and Intensive Care, Faculty of Medicine, Division of Neurointensive Care and Neuroanesthesia, University of Debrecen, H_4032 Debrecen, Nagyerdei krt. 98, Hungary.

Department of Neurology, University of Debrecen, Debrecen, Hungary.

出版信息

Transl Neurosci. 2020 Aug 24;11(1):269-276. doi: 10.1515/tnsci-2020-0115. eCollection 2020.

DOI:10.1515/tnsci-2020-0115

PMID:33335767

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7712159/

Abstract

BACKGROUND

We tested the hypothesis whether there is a correlation between the echogenicity and calcium and water contents of carotid plaques.

PATIENTS AND METHODS

Ninety carotid befurcations from 45 deceased patients were removed during autopsy. Thirty-four plaques were categorized as homogenous echolucent (HEL), homogenous echogenic (HEG) and heterogenous (HE) plaques based on premortem B-mode image. Water content was expressed in % of wet weight. Ca was determined by proton-induced X-ray emission and expressed in ppm. Relative optical density of the B-mode images was analyzed offline using a computer program.

RESULTS

HEL plaques had lower Ca content (medians and IQRs: 6,145 [4,465-6,536 ppm]) compared to HEG (74,100 [15,300-1,44,500-ppm]), ≤ 0.001). HE plaques showed an intermediate calcium content (7,310 [4,840-9,920 ppm]) that was statistically not different from echolucent plaques. Water content of HEG plaques was statistically not different from HEL and HE (HEG:53.5 [35.5-64%], HEL: 73.5 [69.7-78.5%], HE: 70.6 [67.4-73.9%]). HEG plaques had the highest relative optical densities (196 [188-217%]). HEL and HE had similar relative optical densities (HEL: 176 [164-187%], HE: 164 [144-188%], respectively). A significant positive correlation was found between the Ca content and relative optical density of plaques.

CONCLUSIONS

Echogenicity of carotid plaques increases along with their calcium content. Water content may be an important factor in differentiation of different plaques.

摘要

背景

我们检验了颈动脉斑块的回声性与钙含量及水分含量之间是否存在相关性这一假设。

患者与方法

在尸检过程中，从45例 deceased 患者身上取出90个颈动脉分叉处。根据生前B超图像，将34个斑块分为均匀低回声（HEL）、均匀高回声（HEG）和不均匀（HE）斑块。水分含量以湿重的百分比表示。钙通过质子诱导X射线发射测定，并以ppm表示。使用计算机程序离线分析B超图像的相对光密度。

结果

与HEG斑块（74,100 [15,300 - 144,500 ppm]）相比，HEL斑块的钙含量较低（中位数和四分位数间距：6,145 [4,465 - 6,536 ppm]，P≤0.001）。HE斑块的钙含量处于中间水平（7,310 [4,840 - 9,920 ppm]），与低回声斑块在统计学上无差异。HEG斑块的水分含量与HEL和HE斑块在统计学上无差异（HEG：53.5 [35.5 - 64%]，HEL：73.5 [69.7 - 78.5%]，HE：70.6 [67.4 - 73.9%]）。HEG斑块的相对光密度最高（196 [188 - 217%]）。HEL和HE的相对光密度相似（分别为HEL：176 [164 - 187%]，HE：164 [144 - 188%]）。在斑块的钙含量与相对光密度之间发现了显著的正相关。