Islam Yasmin, Khurshid Gibran
Ophthalmology, University of Florida, Gainesville, USA.
Cureus. 2020 Nov 15;12(11):e11493. doi: 10.7759/cureus.11493.
Tobacco and alcohol dependence are known to cause choroidal neovascularization and toxic optic neuropathy, although these typically occur in isolation. In this case report, we describe a 54-year-old male who presented with a juxtafoveal choroidal neovascular membrane (CNVM) in the left eye. Over the course of the next two years, his vision worsened significantly in both eyes, and he developed decreased color vision and paracentral scotomas. Impaired photoreceptor response was detected on full-field electroretinography in both eyes. MRI of the brain and orbits was normal, and laboratory tests for optic neuropathy were within normal limits, except for highly elevated cotinine and nicotine levels. He was in the habit of chewing tobacco nearly constantly, and he admitted to drinking 15-20 alcoholic beverages per week. He was diagnosed with choroidal neovascularization and optic atrophy due to tobacco and alcohol overuse. The effects of tobacco and alcohol use on the health of the choroidal vasculature and optic nerve are discussed in the article.
众所周知，烟草和酒精依赖会导致脉络膜新生血管形成和中毒性视神经病变，尽管这些情况通常单独发生。在本病例报告中，我们描述了一名54岁男性，其左眼出现了黄斑旁脉络膜新生血管膜（CNVM）。在接下来的两年里，他双眼视力显著下降，并出现色觉减退和旁中心暗点。双眼全视野视网膜电图检测到光感受器反应受损。脑部和眼眶的MRI检查正常，除可替宁和尼古丁水平大幅升高外，视神经病变的实验室检查结果均在正常范围内。他几乎一直有嚼烟草的习惯，并且承认每周饮用15至20杯酒精饮料。他被诊断为因过度使用烟草和酒精导致脉络膜新生血管形成和视神经萎缩。本文讨论了烟草和酒精使用对脉络膜血管系统和视神经健康的影响。
