酒精和尼古丁的摄入通过调节补体系统的调控来加剧脉络膜新生血管形成。
Alcohol and nicotine consumption exacerbates choroidal neovascularization by modulating the regulation of complement system.
作者信息
Kaliappan Sankaranarayanan, Jha Purushottam, Lyzogubov Valeriy V, Tytarenko Ruslana G, Bora Nalini S, Bora Puran S
机构信息
Department of Ophthalmology, Pat and Willard Walker Eye Research Center, Jones Eye Institute, 4301 West Markham, Mail Slot 523, Little Rock, AR 72205, United States.
出版信息
FEBS Lett. 2008 Oct 15;582(23-24):3451-8. doi: 10.1016/j.febslet.2008.09.009. Epub 2008 Sep 24.
Abstract
The objective of the present study was to investigate the effect of alcohol and nicotine consumption on the pathogenesis of choroidal neovascularization (CNV) in rats after laser-photocoagulation. Confocal microscopic analysis demonstrated an increase in CNV complex size in rats fed with alcohol (2.3-fold), nicotine (1.9-fold), and the combination of alcohol and nicotine (2.7-fold) compared with the control groups. Immunohistochemical analysis revealed that alcohol and nicotine consumption increased MAC deposition and VEGF expression in laser spots. Expression of CD59 by RT-PCR and Western blot was drastically reduced in the animals that were fed with alcohol, nicotine and alcohol and nicotine compared to those fed with water alone and this was associated with exacerbation of CNV.
摘要
本研究的目的是调查酒精和尼古丁摄入对大鼠激光光凝后脉络膜新生血管（CNV）发病机制的影响。共聚焦显微镜分析表明，与对照组相比，喂食酒精（2.3倍）、尼古丁（1.9倍）以及酒精和尼古丁组合（2.7倍）的大鼠CNV复合体大小增加。免疫组织化学分析显示，酒精和尼古丁摄入会增加激光光斑处膜攻击复合物（MAC）沉积和血管内皮生长因子（VEGF）表达。与仅喂食水的动物相比，喂食酒精、尼古丁以及酒精和尼古丁组合的动物通过逆转录聚合酶链反应（RT-PCR）和蛋白质免疫印迹法检测到的CD59表达显著降低，这与CNV的加重有关。
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