端粒长度与HIV感染者脂肪重新分布的关系
Relationship of Telomere Length to Fat Redistribution in HIV.
作者信息
Iyengar Sanjna, Cȏté Hélène C F, Fitch Kathleen V, Torriani Martin, Feldpausch Meghan, Srinivasa Suman
机构信息
Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
出版信息
Open Forum Infect Dis. 2020 Oct 27;7(12):ofaa523. doi: 10.1093/ofid/ofaa523. eCollection 2020 Dec.
Abstract
Persons with HIV demonstrate increased risk for aging-associated complications and have reduced telomere length (TL) compared with age-matched persons without HIV. Our data show that greater visceral fat is related to reduced TL in HIV, independent of age and smoking. Fat redistribution may be a relevant mediator of TL attrition in HIV.
摘要
与未感染艾滋病毒的年龄匹配者相比，感染艾滋病毒的人出现与衰老相关并发症的风险增加，端粒长度（TL）缩短。我们的数据表明，在感染艾滋病毒的人群中，更多的内脏脂肪与端粒长度缩短有关，这与年龄和吸烟无关。脂肪重新分布可能是艾滋病毒中端粒损耗的一个相关介导因素。
相似文献
1
Relationship of Telomere Length to Fat Redistribution in HIV.端粒长度与HIV感染者脂肪重新分布的关系
Open Forum Infect Dis. 2020 Oct 27;7(12):ofaa523. doi: 10.1093/ofid/ofaa523. eCollection 2020 Dec.
2
Telomere length differences between subcutaneous and visceral adipose tissue in humans.人类皮下脂肪组织与内脏脂肪组织之间的端粒长度差异。
Biochem Biophys Res Commun. 2015 Feb 13;457(3):426-32. doi: 10.1016/j.bbrc.2014.12.122. Epub 2015 Jan 13.
3
Effects of Randomized Controlled Infancy-Onset Dietary Intervention on Leukocyte Telomere Length-The Special Turku Coronary Risk Factor Intervention Project (STRIP).随机对照婴儿期饮食干预对白细胞端粒长度的影响——特殊图尔库冠心病危险因素干预项目（STRIP）。
Nutrients. 2021 Jan 22;13(2):318. doi: 10.3390/nu13020318.
4
Leukocyte telomere length in HIV-infected pregnant women treated with antiretroviral drugs during pregnancy and their uninfected infants.孕期接受抗逆转录病毒药物治疗的HIV感染孕妇及其未感染婴儿的白细胞端粒长度
J Acquir Immune Defic Syndr. 2012 Aug 15;60(5):495-502. doi: 10.1097/QAI.0b013e31825aa89c.
5
Telomere Length, Traditional Risk Factors, Factors Related to Human Immunodeficiency Virus (HIV) and Coronary Artery Disease Events in Swiss Persons Living With HIV.瑞士艾滋病毒感染者的端粒长度、传统风险因素、与人类免疫缺陷病毒（HIV）相关的因素及冠心病事件
Clin Infect Dis. 2021 Oct 5;73(7):e2070-e2076. doi: 10.1093/cid/ciaa1034.
6
Correlation of Telomere Length in Adipose Tissue and Leukocytes and its Association with Postsurgical Weight Loss.脂肪组织和白细胞端粒长度的相关性及其与术后体重减轻的关系。
Obesity (Silver Spring). 2020 Dec;28(12):2424-2430. doi: 10.1002/oby.23017.
7
Increased PAI-1 and tPA antigen levels are reduced with metformin therapy in HIV-infected patients with fat redistribution and insulin resistance.在伴有脂肪重新分布和胰岛素抵抗的HIV感染患者中，二甲双胍治疗可降低升高的纤溶酶原激活物抑制剂-1（PAI-1）和组织型纤溶酶原激活物（tPA）抗原水平。
J Clin Endocrinol Metab. 2001 Feb;86(2):939-43. doi: 10.1210/jcem.86.2.7410.
8
Telomere length and age-dependent telomere attrition: the blood-and-muscle model .端粒长度与年龄相关的端粒损耗：血液与肌肉模型
Can J Physiol Pharmacol. 2019 Apr;97(4):328-334. doi: 10.1139/cjpp-2018-0582. Epub 2019 Mar 15.
9
DNA methylation changes in response to active smoking exposure are associated with leukocyte telomere length among older adults.主动吸烟暴露导致的 DNA 甲基化变化与老年人白细胞端粒长度有关。
Eur J Epidemiol. 2016 Dec;31(12):1231-1241. doi: 10.1007/s10654-016-0210-2. Epub 2016 Nov 10.
10
Baseline biopsychosocial determinants of telomere length and 6-year attrition rate.端粒长度和6年损耗率的基线生物心理社会决定因素。
Psychoneuroendocrinology. 2016 May;67:153-62. doi: 10.1016/j.psyneuen.2016.02.007. Epub 2016 Feb 12.
引用本文的文献
1
TERT single nucleotide polymorphism rs2736098 but not rs2736100 is associated with telomere length in HIV-infected patients on cART.端粒酶逆转录酶单核苷酸多态性 rs2736098 但不是 rs2736100 与接受 cART 的 HIV 感染患者的端粒长度相关。
Mol Biol Rep. 2024 Jan 18;51(1):147. doi: 10.1007/s11033-023-08967-4.
2
HIV Infection, Chromosome Instability, and Micronucleus Formation.人类免疫缺陷病毒感染、染色体不稳定性和微核形成。
Viruses. 2023 Jan 4;15(1):155. doi: 10.3390/v15010155.
本文引用的文献
1
HIV and antiretroviral therapy-related fat alterations.HIV 和抗逆转录病毒治疗相关的脂肪改变。
Nat Rev Dis Primers. 2020 Jun 18;6(1):48. doi: 10.1038/s41572-020-0181-1.
2
Relation of Steatosis to Neurocognitive Function in People Living with HIV.脂肪变性与 HIV 感染者神经认知功能的关系。
Curr HIV Res. 2020;18(3):172-180. doi: 10.2174/1570162X18666200227114310.
3
Measures of Adipose Tissue Redistribution and Atherosclerotic Coronary Plaque in HIV.脂肪组织再分布和动脉粥样硬化斑块在 HIV 中的测量
Obesity (Silver Spring). 2020 Apr;28(4):749-755. doi: 10.1002/oby.22742. Epub 2020 Feb 21.
4
A Monochrome Multiplex Real-Time Quantitative PCR Assay for the Measurement of Mitochondrial DNA Content.一种用于测量线粒体 DNA 含量的单色多重实时定量 PCR 分析方法。
J Mol Diagn. 2018 Sep;20(5):612-620. doi: 10.1016/j.jmoldx.2018.05.001. Epub 2018 Jun 22.
5
Leukocyte Telomere Length in HIV Infection: A Marker of Persistent Immune Aging or Transient Immune Reconstitution?HIV感染中的白细胞端粒长度：持续性免疫衰老的标志物还是短暂免疫重建的标志物？
J Infect Dis. 2018 Oct 5;218(10):1521-1522. doi: 10.1093/infdis/jiy365.
6
Optimization of a Relative Telomere Length Assay by Monochromatic Multiplex Real-Time Quantitative PCR on the LightCycler 480: Sources of Variability and Quality Control Considerations.基于LightCycler 480的单色多重实时定量PCR对相对端粒长度检测方法的优化：变异来源及质量控制考量
J Mol Diagn. 2016 May;18(3):425-437. doi: 10.1016/j.jmoldx.2016.01.004. Epub 2016 Mar 8.
7
Dysfunctional Subcutaneous Fat With Reduced Dicer and Brown Adipose Tissue Gene Expression in HIV-Infected Patients.HIV感染患者中Dicer和棕色脂肪组织基因表达降低导致皮下脂肪功能障碍
J Clin Endocrinol Metab. 2016 Mar;101(3):1225-34. doi: 10.1210/jc.2015-3993. Epub 2016 Jan 12.
8
Telomere length differences between subcutaneous and visceral adipose tissue in humans.人类皮下脂肪组织与内脏脂肪组织之间的端粒长度差异。
Biochem Biophys Res Commun. 2015 Feb 13;457(3):426-32. doi: 10.1016/j.bbrc.2014.12.122. Epub 2015 Jan 13.
9
Soluble CD163 is associated with shortened telomere length in HIV-infected patients.可溶性CD163与HIV感染患者端粒长度缩短有关。
J Acquir Immune Defic Syndr. 2014 Dec 1;67(4):414-418. doi: 10.1097/QAI.0000000000000329.
10
Association between short leukocyte telomere length and HIV infection in a cohort study: No evidence of a relationship with antiretroviral therapy.短白细胞端粒长度与 HIV 感染的队列研究相关性：无证据表明与抗逆转录病毒治疗有关。
Clin Infect Dis. 2014 May;58(9):1322-32. doi: 10.1093/cid/ciu051. Epub 2014 Jan 22.
Zotero 插件