可溶性CD163与HIV感染患者端粒长度缩短有关。
Soluble CD163 is associated with shortened telomere length in HIV-infected patients.
作者信息
Srinivasa Suman, Fitch Kathleen V, Petrow Eva, Burdo Tricia H, Williams Kenneth C, Lo Janet, Cȏté Hélène C F, Grinspoon Steven K
机构信息
Program in Nutritional Metabolism (K.F., S.S., E.P., J.L., S.K.G.), Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Department of Biology, Boston College, Chestnut Hill, MA (T.H.B., K.C.W.).
出版信息
J Acquir Immune Defic Syndr. 2014 Dec 1;67(4):414-418. doi: 10.1097/QAI.0000000000000329.
Abstract
Telomere length (TL) and immune activation markers were measured in a cohort of HIV-infected (n = 102) and age-matched non-HIV-infected (n = 41) men. TL was significantly shorter in HIV-infected compared with non-HIV-infected subjects (P = 0.04). Univariate analysis revealed a strong inverse relationship of TL to sCD163, and thus, monocyte/macrophage activation, among the HIV group (ρ = -0.30, P = 0.003). In multivariate modeling among the whole group, HIV-positive serostatus (P = 0.06) and sCD163 (P = 0.05) remained predictors of TL controlling for age and smoking status. Our data demonstrate that increased immune activation relates to shorter TL in HIV.
摘要
在一组感染HIV的男性（n = 102）和年龄匹配的未感染HIV的男性（n = 41）中测量了端粒长度（TL）和免疫激活标志物。与未感染HIV的受试者相比，感染HIV的受试者的TL显著更短（P = 0.04）。单因素分析显示，在HIV组中，TL与sCD163呈强烈负相关，因此与单核细胞/巨噬细胞激活呈负相关（ρ = -0.30，P = 0.003）。在整个组的多变量建模中，HIV阳性血清状态（P = 0.06）和sCD163（P = 0.05）仍然是控制年龄和吸烟状态后端粒长度的预测因素。我们的数据表明，免疫激活增加与HIV患者端粒长度缩短有关。
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