可溶性CD163与HIV感染患者端粒长度缩短有关。
Soluble CD163 is associated with shortened telomere length in HIV-infected patients.
作者信息
Srinivasa Suman, Fitch Kathleen V, Petrow Eva, Burdo Tricia H, Williams Kenneth C, Lo Janet, Cȏté Hélène C F, Grinspoon Steven K
机构信息
Program in Nutritional Metabolism (K.F., S.S., E.P., J.L., S.K.G.), Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Department of Biology, Boston College, Chestnut Hill, MA (T.H.B., K.C.W.).
出版信息
J Acquir Immune Defic Syndr. 2014 Dec 1;67(4):414-418. doi: 10.1097/QAI.0000000000000329.
Abstract
Telomere length (TL) and immune activation markers were measured in a cohort of HIV-infected (n = 102) and age-matched non-HIV-infected (n = 41) men. TL was significantly shorter in HIV-infected compared with non-HIV-infected subjects (P = 0.04). Univariate analysis revealed a strong inverse relationship of TL to sCD163, and thus, monocyte/macrophage activation, among the HIV group (ρ = -0.30, P = 0.003). In multivariate modeling among the whole group, HIV-positive serostatus (P = 0.06) and sCD163 (P = 0.05) remained predictors of TL controlling for age and smoking status. Our data demonstrate that increased immune activation relates to shorter TL in HIV.
摘要
在一组感染HIV的男性（n = 102）和年龄匹配的未感染HIV的男性（n = 41）中测量了端粒长度（TL）和免疫激活标志物。与未感染HIV的受试者相比，感染HIV的受试者的TL显著更短（P = 0.04）。单因素分析显示，在HIV组中，TL与sCD163呈强烈负相关，因此与单核细胞/巨噬细胞激活呈负相关（ρ = -0.30，P = 0.003）。在整个组的多变量建模中，HIV阳性血清状态（P = 0.06）和sCD163（P = 0.05）仍然是控制年龄和吸烟状态后端粒长度的预测因素。我们的数据表明，免疫激活增加与HIV患者端粒长度缩短有关。
相似文献
1
Soluble CD163 is associated with shortened telomere length in HIV-infected patients.
J Acquir Immune Defic Syndr. 2014 Dec 1;67(4):414-418. doi: 10.1097/QAI.0000000000000329.
2
Soluble CD163, a novel marker of activated macrophages, is elevated and associated with noncalcified coronary plaque in HIV-infected patients.
J Infect Dis. 2011 Oct 15;204(8):1227-36. doi: 10.1093/infdis/jir520.
3
Elevated sCD163 in plasma but not cerebrospinal fluid is a marker of neurocognitive impairment in HIV infection.
AIDS. 2013 Jun 1;27(9):1387-95. doi: 10.1097/QAD.0b013e32836010bd.
4
Soluble CD163 made by monocyte/macrophages is a novel marker of HIV activity in early and chronic infection prior to and after anti-retroviral therapy.
J Infect Dis. 2011 Jul 1;204(1):154-63. doi: 10.1093/infdis/jir214.
5
Reduced sTWEAK and increased sCD163 levels in HIV-infected patients: modulation by antiretroviral treatment, HIV replication and HCV co-infection.
PLoS One. 2014 Mar 4;9(3):e90541. doi: 10.1371/journal.pone.0090541. eCollection 2014.
6
Noncalcified coronary atherosclerotic plaque and immune activation in HIV-infected women.
J Infect Dis. 2013 Dec 1;208(11):1737-46. doi: 10.1093/infdis/jit508. Epub 2013 Sep 16.
7
Brief Report: Macrophage Activation in HIV-2-Infected Patients Is Less Affected by Antiretroviral Treatment-sCD163 in HIV-1, HIV-2, and HIV-1/2 Dually Infected Patients.
J Acquir Immune Defic Syndr. 2016 Jul 1;72(3):254-8. doi: 10.1097/QAI.0000000000000939.
8
Brief Report: Soluble CD163 in CMV-Infected and CMV-Uninfected Subjects on Virologically Suppressive Antiretroviral Therapy in the ICONA Cohort.
J Acquir Immune Defic Syndr. 2017 Mar 1;74(3):347-352. doi: 10.1097/QAI.0000000000001232.
9
Plasma Soluble CD163 Level Independently Predicts All-Cause Mortality in HIV-1-Infected Individuals.
J Infect Dis. 2016 Oct 15;214(8):1198-204. doi: 10.1093/infdis/jiw263. Epub 2016 Jun 28.
10
Soluble CD163 and soluble CD14 plasma levels but not cellular HIV-DNA decrease during successful interferon-free anti-HCV therapy in HIV-1-HCV co-infected patients on effective combined anti-HIV treatment.
Med Microbiol Immunol. 2018 Aug;207(3-4):183-194. doi: 10.1007/s00430-018-0538-1. Epub 2018 Mar 9.
引用本文的文献
1
Identifying methamphetamine use predictors in HIV infection: Immune-dopaminergic signatures in peripheral leukocytes and the role of COMT genotype.
Brain Behav Immun Health. 2024 Oct 5;42:100873. doi: 10.1016/j.bbih.2024.100873. eCollection 2024 Dec.
2
The Impact of HIV and Parasite Single Infection and Coinfection on Telomere Length: A Systematic Review.
Curr Issues Mol Biol. 2024 Jul 8;46(7):7258-7290. doi: 10.3390/cimb46070431.
3
sCD163, sCD28, sCD80, and sCTLA-4 as soluble marker candidates for detecting immunosenescence.
Immun Ageing. 2024 Jan 20;21(1):9. doi: 10.1186/s12979-023-00405-0.
4
ROS-Induced Mitochondrial Dysfunction in CD4 T Cells from ART-Controlled People Living with HIV.
Viruses. 2023 Apr 26;15(5):1061. doi: 10.3390/v15051061.
5
Cellular and molecular insights into incomplete immune recovery in HIV/AIDS patients.
Front Immunol. 2023 May 2;14:1152951. doi: 10.3389/fimmu.2023.1152951. eCollection 2023.
6
The role of immune activation and antigen persistence in acute and long COVID.
J Investig Med. 2023 Jun;71(5):545-562. doi: 10.1177/10815589231158041. Epub 2023 Mar 6.
7
Monocytes in HIV and SIV Infection and Aging: Implications for Inflamm-Aging and Accelerated Aging.
Viruses. 2022 Feb 17;14(2):409. doi: 10.3390/v14020409.
8
Subclinical atherosclerosis and immune activation in young HIV-infected patients with telomere shortening.
Aging (Albany NY). 2021 Jul 26;13(14):18094-18105. doi: 10.18632/aging.203350.
9
Relationship of Telomere Length to Fat Redistribution in HIV.
Open Forum Infect Dis. 2020 Oct 27;7(12):ofaa523. doi: 10.1093/ofid/ofaa523. eCollection 2020 Dec.
10
Biological Aging and Immune Senescence in Children with Perinatally Acquired HIV.
J Immunol Res. 2020 May 16;2020:8041616. doi: 10.1155/2020/8041616. eCollection 2020.
本文引用的文献
1
Accelerated aging of selective brain structures in human immunodeficiency virus infection: a controlled, longitudinal magnetic resonance imaging study.
Neurobiol Aging. 2014 Jul;35(7):1755-68. doi: 10.1016/j.neurobiolaging.2014.01.008. Epub 2014 Jan 13.
2
The relationship between inflammatory biomarkers and telomere length in an occupational prospective cohort study.
PLoS One. 2014 Jan 27;9(1):e87348. doi: 10.1371/journal.pone.0087348. eCollection 2014.
3
Association between short leukocyte telomere length and HIV infection in a cohort study: No evidence of a relationship with antiretroviral therapy.
Clin Infect Dis. 2014 May;58(9):1322-32. doi: 10.1093/cid/ciu051. Epub 2014 Jan 22.
4
Noncalcified coronary atherosclerotic plaque and immune activation in HIV-infected women.
J Infect Dis. 2013 Dec 1;208(11):1737-46. doi: 10.1093/infdis/jit508. Epub 2013 Sep 16.
5
Accelerated biological ageing in HIV-infected individuals in South Africa: a case-control study.
AIDS. 2013 Sep 24;27(15):2375-84. doi: 10.1097/QAD.0b013e328363bf7f.
6
Immune activation in HIV-infected aging women on antiretrovirals--implications for age-associated comorbidities: a cross-sectional pilot study.
PLoS One. 2013 May 28;8(5):e63804. doi: 10.1371/journal.pone.0063804. Print 2013.
7
Blood and dried blood spot telomere length measurement by qPCR: assay considerations.
PLoS One. 2013;8(2):e57787. doi: 10.1371/journal.pone.0057787. Epub 2013 Feb 25.
8
Age-associated changes in monocyte and innate immune activation markers occur more rapidly in HIV infected women.
PLoS One. 2013;8(1):e55279. doi: 10.1371/journal.pone.0055279. Epub 2013 Jan 24.
9
Inhibition of telomerase activity by human immunodeficiency virus (HIV) nucleos(t)ide reverse transcriptase inhibitors: a potential factor contributing to HIV-associated accelerated aging.
J Infect Dis. 2013 Apr;207(7):1157-65. doi: 10.1093/infdis/jit006. Epub 2013 Jan 9.
10
Arterial inflammation in patients with HIV.
JAMA. 2012 Jul 25;308(4):379-86. doi: 10.1001/jama.2012.6698.
Zotero 插件