N6-甲基腺苷修饰在长链非编码RNA中的功能。
The functions of N6-methyladenosine modification in lncRNAs.
作者信息
He Rong-Zhang, Jiang Jing, Luo Di-Xian
机构信息
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
Translational Medicine Institute, National & Local Joint Engineering Laboratory for High-through Molecular Diagnosis Technology, Collaborative Research Center for Post-doctoral Mobile Stations of Central South University, Affiliated the First People's Hospital of Chenzhou, University of South China, Chenzhou, 423000, China.
出版信息
Genes Dis. 2020 Mar 19;7(4):598-605. doi: 10.1016/j.gendis.2020.03.005. eCollection 2020 Dec.
Increasing evidence indicates that mRNAs are often subject to posttranscriptional modifications. Among them, N6-methyladenosine (m6A), which has been shown to play key roles in RNA splicing, stability, nuclear export, and translation, is the most abundant modification of RNA. Extensive studies of m6A modification of mRNAs have been carried out, while little is known about m6A modification of long non-coding RNAs (lncRNAs). Recently, several studies reported m6A modification of lncRNAs. In this review, we focus on these m6A-modified lncRNAs and discuss possible functions of m6A modification.
越来越多的证据表明，mRNA常常会经历转录后修饰。其中，N6-甲基腺苷（m6A）是RNA中最丰富的修饰，已被证明在RNA剪接、稳定性、核输出和翻译中起关键作用。人们已经对mRNA的m6A修饰进行了广泛研究，而对于长链非编码RNA（lncRNA）的m6A修饰却知之甚少。最近，有几项研究报道了lncRNA的m6A修饰。在这篇综述中，我们聚焦于这些m6A修饰的lncRNA，并讨论m6A修饰可能的功能。
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