Hu Xiaoge, Lei Xiangxiang, Guo Jinhui, Fu Wen, Sun Wen, Lu Qiliang, Su Wei, Xu Qiuran, Tu Kangsheng
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
The Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.
Front Oncol. 2022 Jul 22;12:927640. doi: 10.3389/fonc.2022.927640. eCollection 2022.
Pancreatic cancer (PC) is one of the most common malignant cancers, ranking the seventh highest causes of cancer-related deaths globally. Recently, RNA N6-methyladenosine (m6A) is emerging as one of the most abundant RNA modifications in eukaryote cells, involved in multiple RNA processes including RNA translocation, alternative splicing, maturation, stability, and degradation. As reported, m6A was dynamically and reversibly regulated by its "writers", "erasers", and "readers", Increasing evidence has revealed the vital role of m6A modification in the development of multiple types of cancers including PC. Currently, aberrant m6A modification level has been found in both PC tissues and cell lines. Moreover, abnormal expressions of m6A regulators and m6A-modified genes have been reported to contribute to the malignant development of PC. Here in this review, we will focus on the function and molecular mechanism of m6A-modulated RNAs including coding RNAs as well as non-coding RNAs. Then the m6A regulators will be summarized to reveal their potential applications in the clinical diagnosis, prognosis, and therapeutics of PC.
胰腺癌（PC）是最常见的恶性肿瘤之一，在全球癌症相关死亡原因中排名第七。最近，RNA N6-甲基腺苷（m6A）作为真核细胞中最丰富的RNA修饰之一出现，参与多种RNA过程，包括RNA易位、可变剪接、成熟、稳定性和降解。据报道，m6A由其“书写者”“擦除者”和“阅读者”进行动态可逆调控，越来越多的证据表明m6A修饰在包括PC在内的多种癌症发展中起着至关重要的作用。目前，在PC组织和细胞系中均发现m6A修饰水平异常。此外，据报道m6A调节剂和m6A修饰基因的异常表达促进了PC的恶性发展。在本综述中，我们将重点关注m6A调控的RNA（包括编码RNA和非编码RNA）的功能和分子机制。然后总结m6A调节剂，以揭示它们在PC临床诊断、预后和治疗中的潜在应用。
