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新的器官共享联合网络分配标准对心脏移植实践及结果的影响。

Impact of New UNOS Allocation Criteria on Heart Transplant Practices and Outcomes.

作者信息

Liu Jason, Yang Bin Q, Itoh Akinobu, Masood Mohammed Faraz, Hartupee Justin C, Schilling Joel D

机构信息

Department of Medicine, Division of Cardiology, Barnes-Jewish Hospital/Washington University School of Medicine, St. Louis, MO.

Department of Surgery, Division of Cardiothoracic Surgery, Barnes-Jewish Hospital/Washington University School of Medicine, St. Louis, MO.

出版信息

Transplant Direct. 2020 Dec 15;7(1):e642. doi: 10.1097/TXD.0000000000001088. eCollection 2021 Jan.

Abstract

BACKGROUND

In October 2018, a new heart allocation policy was implemented with intent of prioritizing the sickest patients and decreasing waitlist time. We examined the effects of the new policy on transplant practices and outcomes 1 year before and 1 year after the change.

METHODS

Transplant recipients from October 2017 to September 2019 at our institution were identified and divided into 2 cohorts, a preallocation and postallocation criteria change. Patient demographics, clinical data, and bridging strategy were assessed. Early outcomes including ischemic time, severe primary graft dysfunction, need for renal replacement therapy, and duration of hospital stay were investigated.

RESULTS

In the 12 months before the change, 38 patients were transplanted as compared to 33 patients in the 12 months after the change. The average wait-time to transplant decreased after the allocation change (49 versus 313 d, = 0.02). Patients were more likely to be bridged with an intra-aortic balloon pump (45% versus 3%) and less likely to be supported with a durable left ventricular assist device (LVAD) after the change (24% versus 82%). There was an increase in total ischemic time after the change (177 versus 117 min, ≤ 0.01). There were no significant differences in other early posttransplant outcomes.

CONCLUSIONS

Implementation of the new allocation system for heart transplantation resulted in dramatic changes in the bridging strategy utilized at our institution. Temporary mechanical support usage increased following the change and the number of recipients supported with durable LVADs decreased. Early posttransplant outcomes appear similar.

摘要

背景

2018年10月,一项新的心脏分配政策开始实施,旨在优先考虑病情最严重的患者并缩短等待名单时间。我们研究了这一政策在改变前后1年对移植实践和结果的影响。

方法

确定了2017年10月至2019年9月在我们机构接受移植的受者,并将其分为2个队列,即分配标准改变前和改变后。评估了患者的人口统计学、临床数据和过渡策略。研究了早期结果,包括缺血时间、严重原发性移植物功能障碍、肾脏替代治疗需求和住院时间。

结果

改变前的12个月中有38例患者接受了移植,而改变后的12个月中有33例患者接受了移植。分配改变后,平均移植等待时间缩短(49天对313天,P = 0.02)。改变后,患者更有可能使用主动脉内球囊泵进行过渡(45%对3%),而使用持久左心室辅助装置(LVAD)进行支持的可能性降低(24%对82%)。改变后总缺血时间增加(177分钟对117分钟,P≤0.01)。移植后其他早期结果无显著差异。

结论

心脏移植新分配系统的实施导致了我们机构使用的过渡策略发生了巨大变化。改变后临时机械支持的使用增加,而使用持久LVAD支持的受者数量减少。移植后早期结果似乎相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19c1/7738116/d699872578b6/txd-7-e642-g001.jpg

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