Jin Miaomiao, Niu Xiaohong, Liu Yan, Zhang Dong, Yuan Danni, Shen Huimin
Department of Endocrinology, The Heji Affiliated Hospital of Changzhi Medical College, 271 Taihang East Street, Luzhou District, Changzhi 046011, Shanxi, China.
Department of Physiology, Changzhi Medical College, Changzhi 046000, Shanxi, China.
Open Med (Wars). 2020 Jul 18;15(1):689-696. doi: 10.1515/med-2020-0212. eCollection 2020.
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of liver disease worldwide, and no effective treatment exists until now. Glucagon-like peptide-1 receptor agonists are becoming the preferred therapeutic option for the management of obesity and are becoming the preferred treatment options for the management of both NAFLD and type 2 diabetes mellitus, but the molecular mechanisms are still unclear.
Forty-five healthy male Wistar rats were divided into three groups: normal control, high-fat diet (HFD) group, HFD + liraglutide (100 mg/kg body weight) group. Biochemical parameters and adipokine levels were examined in the serum of rats. In order to judge the degree of steatosis of NAFLD, the magnetic resonance imaging and histopathology of the liver were also studied.
Liraglutide caused a significant decrease in the serum fasting glucose and improved the insulin resistance, dyslipidemia, and liver enzymes. It reduced the adipokine level, and alleviated the histopathology of liver of rats in the steatosis, ballooning, and lobular inflammation when compared to the HFD group. Thus, liraglutide demonstrated amelioration of NAFLD by decreasing the adipokine levels in this animal model and seems to be a promising molecule for the management of NAFLD.
非酒精性脂肪性肝病（NAFLD）是全球肝病的主要病因，目前尚无有效的治疗方法。胰高血糖素样肽-1受体激动剂正成为治疗肥胖症的首选治疗选择，并且正成为治疗NAFLD和2型糖尿病的首选治疗选择，但分子机制仍不清楚。
将45只健康雄性Wistar大鼠分为三组：正常对照组、高脂饮食（HFD）组、HFD + 利拉鲁肽（100mg/kg体重）组。检测大鼠血清中的生化参数和脂肪因子水平。为了判断NAFLD的脂肪变性程度，还研究了肝脏的磁共振成像和组织病理学。
利拉鲁肽可显著降低血清空腹血糖，并改善胰岛素抵抗、血脂异常和肝酶。与HFD组相比，它降低了脂肪因子水平，并减轻了大鼠肝脏在脂肪变性、气球样变和小叶炎症方面的组织病理学变化。因此，在该动物模型中，利拉鲁肽通过降低脂肪因子水平显示出对NAFLD的改善作用，似乎是一种有前途的用于治疗NAFLD的分子。
