Mousavi Zohreh, Ganji Azita, Farrokh Tehrani Donya, Bahari Ali, EsmaeilZadeh Abbas, Delghandi Mehdi
Endocrine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Gastroenterology and Hepatology Research Center. Mashhad University of Medical Sciences & Department of Gastroenterology and Hepatology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Med J Islam Repub Iran. 2017 May 28;31:28. doi: 10.18869/mjiri.31.28. eCollection 2017.
Metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD) is a common public health problem. Visfatin is secreted by visceral adipose tissue and is an adipocytokine. It could be a pro-inflammatory adipocytokine and is related to the metabolic syndrome and non-alcoholic fatty liver disease. This study evaluated the association between visfatin levels in patients with the metabolic syndrome with and without non-alcoholic fatty liver disease (NAFLD). In this cross-sectional study, 120 patients with metabolic syndrome were selected. They were categorized into two groups, patients with fatty liver (n=70) and without fatty liver disease (n=50). Laboratory and anthropometric options such as age, sex, systolic blood pressure, fasting blood sugar, lipid profile, liver enzymes, uric acid, visfatin, insulin, BMI, waist circumference, and TNF-α were measured. The chi-square test, Mann-Whitney, t test, Spearman and Pearson correlations were used for the data analysis. : There was a significant difference between the fatty liver and non-fatty liver disease with visfatin, BMI, FBS and lipid profile (p<0.05). The mean±SD level of visfatin was 37.1±1.7 ng/dl in the non-fatty liver and was 44.4±1.5 ng/dl in fatty liver participants (p=0.02). 59% of patients with metabolic syndrome had fatty liver in ultrasonography. According to this study, there was a correlation between visfatin levels and fatty liver disease.
代谢综合征（MS）和非酒精性脂肪性肝病（NAFLD）是常见的公共卫生问题。内脂素由内脏脂肪组织分泌，是一种脂肪细胞因子。它可能是一种促炎脂肪细胞因子，与代谢综合征和非酒精性脂肪性肝病有关。本研究评估了合并或不合并非酒精性脂肪性肝病（NAFLD）的代谢综合征患者的内脂素水平之间的关联。在这项横断面研究中，选取了120例代谢综合征患者。他们被分为两组，脂肪肝患者（n = 70）和无脂肪肝疾病患者（n = 50）。测量了年龄、性别、收缩压、空腹血糖、血脂谱、肝酶、尿酸、内脂素、胰岛素、BMI、腰围和TNF-α等实验室和人体测量指标。采用卡方检验、曼-惠特尼检验、t检验、Spearman和Pearson相关性分析进行数据分析。结果显示：脂肪肝与非脂肪肝患者在内脂素、BMI、空腹血糖和血脂谱方面存在显著差异（p<0.05）。非脂肪肝患者内脂素的平均±标准差水平为37.1±1.7 ng/dl，脂肪肝患者为44.4±1.5 ng/dl（p = 0.02）。59%的代谢综合征患者超声检查显示有脂肪肝。根据本研究，内脂素水平与脂肪性肝病之间存在相关性。
