焦虑症会促进头颈癌的发展吗？
Might anxiety disorders promote head and neck cancer development?
作者信息
de Souza Marcela Gonçalves, Gomes Emisael Stênio Batista, Costa Lorena Barbosa, Andrade Amanda Dias Silva, de Jesus Sabrina Ferreira, de Paula Daniela Paola Santos, Rocha Rogério Gonçalves da, Santos Sérgio Henrique Sousa, de Paula Alfredo Maurício Batista, Farias Lucyana Conceição, Guimaraes André Luiz Sena
机构信息
Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.
Institute of Agricultural Sciences, Food Engineering College, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, Brazil.
出版信息
IBRO Rep. 2020 Jun 20;9:9-13. doi: 10.1016/j.ibror.2020.06.001. eCollection 2020 Dec.
Cancer patients present a higher risk of experiencing anxiety disorders (AD). However, it is not clear if AD might be associated with cancer development. Thus, our study aimed to evaluate if AD might be related to head and neck squamous cell carcinoma (HNSCC) development. The combination of an applied animal basic study and a retrospective diagnostic case and control study in patients was performed. As a result, we obtained that stress reduced the locomotor activity of the animals in the group stress and stress + 4NqO (p < 0.0001). The stress showed no influence on the progression of neoplasia in mice. In the same way, the case group did not present differences in anxiety scores in comparison to control. Moreover, no association between HNSCC staging and anxiety scores was observed. In conclusion, our in vivo findings in humans and animals have shown that there is no relationship between AD and oral squamous cell carcinoma.
癌症患者出现焦虑症（AD）的风险更高。然而，目前尚不清楚AD是否可能与癌症发展有关。因此，我们的研究旨在评估AD是否可能与头颈部鳞状细胞癌（HNSCC）的发展有关。我们进行了一项应用动物基础研究与患者回顾性诊断病例对照研究相结合的研究。结果，我们发现应激降低了应激组和应激 + 4NqO组动物的运动活性（p < 0.0001）。应激对小鼠肿瘤形成的进展没有影响。同样，病例组与对照组相比，焦虑评分没有差异。此外，未观察到HNSCC分期与焦虑评分之间存在关联。总之，我们在人和动物身上的体内研究结果表明，AD与口腔鳞状细胞癌之间没有关系。
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