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在新冠疫情期间取消择期心脏介入手术的后果。

Consequences of canceling elective invasive cardiac procedures during Covid-19 outbreak.

机构信息

Hospital Universitario La Paz, IdiPAZ, CIBER-CV, Madrid, Spain.

Hospital La Fe, Valencia, Spain.

出版信息

Catheter Cardiovasc Interv. 2021 Apr 1;97(5):927-937. doi: 10.1002/ccd.29433. Epub 2020 Dec 17.

Abstract

BACKGROUND

During COVID-19 pandemic in Spain, elective procedures were canceled or postponed, mainly due to health care systems overwhelming.

OBJECTIVE

The objective of this study was to evaluate the consequences of interrupting invasive procedures in patients with chronic cardiac diseases due to the COVID-19 outbreak in Spain.

METHODS

The study population is comprised of 2,158 patients that were pending on elective cardiac invasive procedures in 37 hospitals in Spain on the 14th of March 2020, when a state of alarm and subsequent lockdown was declared in Spain due to the COVID-19 pandemic. These patients were followed-up until April 31th.

RESULTS

Out of the 2,158 patients, 36 (1.7%) died. Mortality was significantly higher in patients pending on structural procedures (4.5% vs. 0.8%, respectively; p < .001), in those >80 year-old (5.1% vs. 0.7%, p < .001), and in presence of diabetes (2.7% vs. 0.9%, p = .001), hypertension (2.0% vs. 0.6%, p = .014), hypercholesterolemia (2.0% vs. 0.9%, p = .026) [Correction added on December 23, 2020, after first online publication: as per Dr. Moreno's request changes in p-values were made after original publication in Abstract.], chronic renal failure (6.0% vs. 1.2%, p < .001), NYHA > II (3.8% vs. 1.2%, p = .001), and CCS > II (4.2% vs. 1.4%, p = .013), whereas was it was significantly lower in smokers (0.5% vs. 1.9%, p = .013). Multivariable analysis identified age > 80, diabetes, renal failure and CCS > II as independent predictors for mortality.

CONCLUSION

Mortality at 45 days during COVID-19 outbreak in patients with chronic cardiovascular diseases included in a waiting list due to cancellation of invasive elective procedures was 1.7%. Some clinical characteristics may be of help in patient selection for being promptly treated when similar situations happen in the future.

摘要

背景

在西班牙的 COVID-19 大流行期间,主要由于医疗保健系统不堪重负,择期手术被取消或推迟。

目的

本研究的目的是评估由于西班牙 COVID-19 爆发而中断慢性心脏病患者的侵入性手术的后果。

方法

研究人群由 2158 名患者组成,他们于 2020 年 3 月 14 日在西班牙 37 家医院等待择期心脏介入手术,当时由于 COVID-19 大流行,西班牙宣布进入紧急状态和随后的封锁。这些患者一直随访到 4 月 31 日。

结果

在 2158 名患者中,有 36 名(1.7%)死亡。在等待结构性手术的患者中,死亡率明显更高(4.5%对 0.8%;p <0.001),年龄> 80 岁的患者(5.1%对 0.7%;p <0.001),患有糖尿病(2.7%对 0.9%;p =0.001),高血压(2.0%对 0.6%;p =0.014),高胆固醇血症(2.0%对 0.9%;p =0.026)[更正于 2020 年 12 月 23 日添加,在原始出版后根据 Moreno 博士的要求对 p 值进行了更改。],慢性肾功能衰竭(6.0%对 1.2%;p <0.001),NYHA > II(3.8%对 1.2%;p =0.001),CCS > II(4.2%对 1.4%;p =0.013),而吸烟者的死亡率明显较低(0.5%对 1.9%;p =0.013)。多变量分析确定年龄> 80 岁,糖尿病,肾功能衰竭和 CCS > II 是死亡的独立预测因素。

结论

在由于取消择期侵入性手术而被列入候补名单的患有慢性心血管疾病的患者中,COVID-19 大流行期间 45 天的死亡率为 1.7%。在未来发生类似情况时,某些临床特征可能有助于选择及时接受治疗的患者。

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