Fortis CDOC Hospital, Chirag Enclave, New Delhi, India.
Fortis CDOC Hospital, Chirag Enclave, New Delhi, India.
Diabetes Metab Syndr. 2020 Nov-Dec;14(6):2205-2210. doi: 10.1016/j.dsx.2020.11.010. Epub 2020 Nov 12.
Asian Indian patients with type 2 diabetes mellitus (T2DM) have a high cardiovascular risk even at young age. There is a need to assess this increased risk and identify atherosclerosis early so that appropriate measures for risk reduction can be taken. We aimed to study carotid-femoral pulse wave velocity (Cf-PWV), a non-invasive indicator of atherosclerosis, in patients with diabetes below 50 years of age and its correlation with markers of obesity and other cardiovascular risk factors.
Patients (n, 299) with T2DM below 50 years of age underwent measurement of Cf-PWV by applanation tonometry. Anthropometric parameters, blood pressure, liver span, glycosylated hemoglobin, serum lipid profile, urinary microalbumin, ankle brachial index and carotid intima media thickness were measured.
Data show that 32.4% of patients had high Cf-PWV, with mean values higher in males than females. On stepwise multiple linear regression analysis, the significant independent determinants of PWV were age, systolic blood pressure, waist circumference, microalbumin and liver span.
About one third patients with T2DM less than 50 years of age, in north India have increased arterial stiffness which correlates with blood pressure, abdominal obesity, liver size and microalbumin, indicating increased risk for coronary artery disease.
亚洲印度 2 型糖尿病（T2DM）患者即使在年轻时期也具有较高的心血管风险。因此，需要评估这种增加的风险并尽早发现动脉粥样硬化，以便采取适当的降低风险措施。我们旨在研究颈动脉-股动脉脉搏波速度（Cf-PWV），一种动脉粥样硬化的非侵入性指标，在 50 岁以下的糖尿病患者中的情况，并研究其与肥胖标志物和其他心血管危险因素的相关性。
299 名年龄在 50 岁以下的 T2DM 患者接受了平板压力测量法的 Cf-PWV 测量。测量了人体测量参数、血压、肝径、糖化血红蛋白、血脂谱、尿微量白蛋白、踝臂指数和颈动脉内膜中层厚度。
数据显示，32.4%的患者 Cf-PWV 较高，男性的平均值高于女性。在逐步多元线性回归分析中，PWV 的显著独立决定因素是年龄、收缩压、腰围、微量白蛋白和肝径。
在印度北部，约三分之一年龄在 50 岁以下的 T2DM 患者动脉僵硬程度增加，这与血压、腹部肥胖、肝脏大小和微量白蛋白相关，表明其冠心病风险增加。
