Department of Natural Medicine, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
College of Science, Northwest A&F University, 22 Xinong Road, Shaanxi, Yangling 712100, China.
Org Biomol Chem. 2021 Jan 21;19(2):457-466. doi: 10.1039/d0ob02158j.
An efficient approach to access functionalized (2,3-dihydroisoxazol-4-yl) ketones has been developed by reacting nitrones 4 with ynones 7 or terminal ynones 10 in a one-pot fashion. The reaction went through a formal Sc(OTf)3-catalyzed [3 + 2]-cycloaddition process to generate a number of functionalized (2,3-dihydroisoxazol-4-yl) ketones 11aa-11aw, 11ba-11la and 12aa-12ae in moderate to good yields.
通过在一锅法中使硝酮 4 与炔酮 7 或末端炔酮 10 反应，开发出一种获得功能化（2,3-二氢异恶唑-4-基）酮的有效方法。该反应通过形式上的 Sc(OTf)3 催化的 [3 + 2]-环加成过程生成了多种功能化的（2,3-二氢异恶唑-4-基）酮 11aa-11aw、11ba-11la 和 12aa-12ae，产率中等至良好。
