Houston Methodist Research Institute, Houston, TX, USA.
Int J Dev Biol. 2020;64(10-11-12):465-469. doi: 10.1387/ijdb.200242jc.
Mesenchymal stem cells (MSCs) are used as therapeutic agents for the treatment of a wide spectrum of diseases, as well as for the regeneration and healing of burns and wounds. MSCs have an immunomodulatory effect and influence the phenotype and functions of immune cells, including macrophages, which in turn prime and license the MSCs. We discuss the new findings on the feedback loop between MSCs and macrophages and its consequences on the outcome of MSC therapies.
间充质干细胞（MSCs）被用作治疗广泛疾病的治疗剂，以及烧伤和创伤的再生和愈合。MSCs 具有免疫调节作用，并影响免疫细胞的表型和功能，包括巨噬细胞，巨噬细胞反过来又启动和授权 MSCs。我们讨论了 MSCs 和巨噬细胞之间的反馈回路的新发现及其对 MSC 治疗结果的影响。
