分析 NudCD1 和 NF-κΒ 在肾癌早期检测和病程评估中的作用。

Analysis of NudCD1 and NF-κΒ in the early detection and course evaluation of renal cancer.

机构信息

Department of Oncology, The Fifth Hospital of Wuhan, Wuhan, Hubei, China.

出版信息

Eur Rev Med Pharmacol Sci. 2020 Dec;24(23):12109-12115. doi: 10.26355/eurrev_202012_23999.

DOI:10.26355/eurrev_202012_23999

PMID:33336728

Abstract

OBJECTIVE

Early detection and effective evaluation are helpful for renal cancer diagnosis and treatment. NudCD1 and NF-κΒ are abnormally expressed in tumors and inflammations. However, their role in early detection and course evaluation of renal cancer has not been reported.

PATIENTS AND METHODS

The serum of clinically diagnosed renal cancer patients and healthy volunteers (control group) were collected to measure the expressions of NudCD1 and NF-κΒ mRNA by Real time PCR.

RESULTS

NudCD1 and NF-κΒ mRNA in renal cancer patients were significantly upregulated compared to controls (p<0.05). NudCD1 was positively correlated with tumor diameter, TNM stage, lymph node metastasis, degree of differentiation, and distant metastasis (p<0.05); whereas, NF-κΒ was positively related to TNM stage, lymph node metastasis, and distant metastasis (p<0.05) but not to tumor diameter and differentiation degree. NudCD1 and NF-κΒ were positively correlated. The combined detection improved the diagnostic specificity and sensitivity of renal cancer.

CONCLUSIONS

The expression of NudCD1 and NF-κΒ is increased in renal cancer and is correlated with renal cancer clinicopathological characteristics. The combined detection of NudCD1 and NF-κΒ can improve the early diagnosis of kidney cancer.

摘要

目的

早期检测和有效评估有助于肾癌的诊断和治疗。NudCD1 和 NF-κΒ 在肿瘤和炎症中异常表达。然而，它们在肾癌的早期检测和病程评估中的作用尚未被报道。

患者和方法

收集临床诊断为肾癌患者和健康志愿者（对照组）的血清，通过实时 PCR 测量 NudCD1 和 NF-κΒ mRNA 的表达。

结果

与对照组相比，肾癌患者的 NudCD1 和 NF-κΒ mRNA 明显上调（p<0.05）。NudCD1 与肿瘤直径、TNM 分期、淋巴结转移、分化程度和远处转移呈正相关（p<0.05）；而 NF-κΒ 与 TNM 分期、淋巴结转移和远处转移呈正相关（p<0.05），但与肿瘤直径和分化程度无关。NudCD1 和 NF-κΒ 呈正相关。联合检测提高了肾癌的诊断特异性和敏感性。