Neurology Unit, Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
Department of Psychiatry, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
Epileptic Disord. 2020 Dec 1;22(6):828-833. doi: 10.1684/epd.2020.1233.
Super-refractory status epilepticus (SRSE) is a neurocritical emergency, associated with significant morbidity and mortality. The precise pathophysiology is still not completely understood. The likelihood of spontaneous seizure termination reduces with time, and it is of paramount importance to abort status in order to prevent permanent long-term neurological sequelae and death. A few neuroprotective strategies, such as general anaesthesia, steroids, ketogenic diet and hypothermia, have been used to treat SRSE, however, the clinical outcome remains inconclusive. We herein present two cases of SRSE, which were successfully treated with electroconvulsive therapy (ECT) after failing all pharmacological measures.
超难治性癫痫持续状态（SRSE）是一种神经危重症，与较高的发病率和死亡率相关。其确切的病理生理学机制仍不完全清楚。随着时间的推移，自发性癫痫终止的可能性降低，因此终止癫痫持续状态对于预防永久性长期神经后遗症和死亡至关重要。一些神经保护策略，如全身麻醉、类固醇、生酮饮食和低温，已被用于治疗 SRSE，但临床结果仍不确定。我们在此介绍两例 SRSE 患者，在所有药物治疗措施失败后，均成功地接受了电休克治疗（ECT）。
