Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
J Endocrinol. 2021 Feb;248(2):R41-R50. doi: 10.1530/JOE-20-0511.
Tissue parenchyma is the functional unit of an organ and all of the remaining cells within that organ collectively make up the tissue stroma. The stroma includes fibroblasts, endothelial cells, immune cells, and nerves. Interactions between stromal and epithelial cells are essential for tissue development and healing after injury. These interactions are governed by growth factors, inflammatory cytokines and hormone signaling cascades. The steroid receptor coactivator (SRC) family of proteins includes three transcriptional coactivators that facilitate the assembly of multi-protein complexes to induce gene expression in response to activation of many cellular transcription factor signaling cascades. They are ubiquitously expressed and are especially critical for the developmental function of steroid hormone responsive tissues. The SRCs are overexpressed in multiple cancers including breast, ovarian, prostate and endometrial cancers. In this review, we focus on the role of the SRCs in regulating the functions of stromal cell components responsible for angiogenesis, inflammation and cell differentiation.
组织实质是器官的功能单位，而该器官内的所有剩余细胞共同构成组织基质。基质包括成纤维细胞、内皮细胞、免疫细胞和神经。基质细胞与上皮细胞之间的相互作用对于组织发育和损伤后的愈合至关重要。这些相互作用受生长因子、炎症细胞因子和激素信号级联的调控。类固醇受体共激活剂（SRC）家族蛋白包括三种转录共激活剂，它们促进多蛋白复合物的组装，以响应许多细胞转录因子信号级联的激活诱导基因表达。它们广泛表达，对于类固醇激素反应组织的发育功能尤为关键。SRC 在多种癌症中过度表达，包括乳腺癌、卵巢癌、前列腺癌和子宫内膜癌。在这篇综述中，我们重点讨论了 SRC 在调节负责血管生成、炎症和细胞分化的基质细胞成分的功能中的作用。
