Institute of Anatomy, Christian-Albrechts-University of Kiel, Kiel, Germany.
Department of Neurology, University Hospital Schleswig-Holstein, Christian-Albrechts-University of Kiel, Kiel, Germany.
J Parkinsons Dis. 2021;11(1):171-176. doi: 10.3233/JPD-202258.
Still little is known about the nature of the gastrointestinal pathological alterations occurring in Parkinson's disease (PD). Here, we used multiplexed mRNA profiling to measure the expression of a panel of 770 genes related to neuropathological processes in deep submucosal rectal biopsies of PD patients and healthy controls. Altered enteric neuropathological traits based on the expression of 22 genes related to neuroglial and mitochondrial functions, vesicle trafficking and inflammation was observed in 9 out of 12 PD patients in comparison to healthy controls. These results provide new evidences that intestinal neuropathological alterations may occur in a large proportion of PD patients.
目前对于帕金森病（PD）患者胃肠道病理改变的性质仍知之甚少。在这里，我们使用多重 mRNA 谱分析来测量深黏膜直肠活检中与神经病理过程相关的 770 个基因的表达。与健康对照组相比，在 12 名 PD 患者中的 9 名患者中观察到基于与神经胶质和线粒体功能、囊泡运输和炎症相关的 22 个基因表达的改变的肠神经病理特征。这些结果提供了新的证据，表明肠道神经病理改变可能发生在很大一部分 PD 患者中。
