Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada (LN); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada (LN, TR, AW, LT, ZS); Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada (TR, ZS); Medical Sciences Graduate Program, McMaster University, Hamilton, Ontario, Canada (NS); Department of Medicine, McMaster University, Hamilton, Ontario, Canada (BD, AW); Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada (JP); Biostatistics Unit, Research Institute at St Joseph's Healthcare, Hamilton, Ontario, Canada (LT).
J Addict Med. 2021;15(5):370-375. doi: 10.1097/ADM.0000000000000781.
Cannabis use is associated with suicide risk in the general population; however, it is unknown if this association is also present in patients with opioid use disorder (OUD). The purpose of this study is to investigate the association between cannabis use and suicidal ideation in patients with OUD.
We conducted a multivariable logistic regression analysis to assess the association between cannabis use and suicidal ideation, amongst a large cohort of patients with OUD. Current cannabis use and suicidal ideation over the past 30 days were obtained by self-report.
Cross-sectional data from 2335 participants with OUD were included in the analysis, of whom 51% report current cannabis use. We found a positive association between cannabis use and suicidal ideation (OR = 1.41, 95% CI 1.11, 1.80, P = 0.005). We found that men (OR = 1.84, 95% CI 1.44, 2.35, P < 0.001), younger individuals (OR = 1.02, 95% CI 1.01, 1.03), P = 0.004), and that those with more symptoms of anxiety or depression (OR = 1.16, 95% CI 1.15, 1.18, P < 0.001) were more likely to report suicidal ideation.
Cannabis use is associated with a heightened propensity for suicidal ideation amongst patients with OUD, who are already a high-risk population. Further research into the potential harms of cannabis use in this population is required given the prevalence of its use and potential benefits in mitigating opioid withdrawal.
大麻使用与普通人群的自杀风险相关；然而，在患有阿片类药物使用障碍（OUD）的患者中，这种关联是否存在尚不清楚。本研究的目的是调查 OUD 患者中大麻使用与自杀意念之间的关联。
我们进行了多变量逻辑回归分析，以评估 OUD 患者中大麻使用与自杀意念之间的关联。通过自我报告获得当前大麻使用和过去 30 天内的自杀意念。
纳入了 2335 名患有 OUD 的参与者的横断面数据，其中 51%报告当前大麻使用。我们发现大麻使用与自杀意念之间存在正相关（OR=1.41，95%CI 1.11，1.80，P=0.005）。我们发现男性（OR=1.84，95%CI 1.44，2.35，P<0.001）、年轻个体（OR=1.02，95%CI 1.01，1.03，P=0.004）和焦虑或抑郁症状更多的个体（OR=1.16，95%CI 1.15，1.18，P<0.001）更有可能报告自杀意念。
大麻使用与 OUD 患者自杀意念的发生风险增加相关，而这些患者已经是高风险人群。鉴于大麻在该人群中的普遍使用及其在缓解阿片类药物戒断方面的潜在益处，需要进一步研究大麻使用的潜在危害。
