Department of Anesthesiology and Pain Medicine, University of Toronto, Ontario, Canada.
Department of Psychiatry, University of Toronto, Ontario, Canada.
Can J Psychiatry. 2022 Apr;67(4):259-267. doi: 10.1177/0706743721996112. Epub 2021 Mar 1.
With the increasing prevalence of cannabis use, there is a growing concern about its association with depression and suicidality. The aim of this study was to examine the relationship between recent cannabis use and suicidal ideation using a nationally representative data set.
A cross-sectional analysis of adults was undertaken using National Health and Nutrition Examination Survey data from 2005 to 2018. Participants were dichotomized by whether or not they had used cannabis in the past 30 days. The primary outcome was suicidal ideation, and secondary outcomes were depression and having recently seen a mental health professional. Multiple logistic regression was used to adjust for potential confounders, and survey sample weights were considered in the model.
Compared to those with no recent use ( = 18,599), recent users ( = 3,127) were more likely to have experienced suicidal ideation in the past 2 weeks (adjusted odds ratio [aOR] 1.54, 95% CI, 1.19 to 2.00, = 0.001), be depressed (aOR 1.53, 95% CI, 1.29 to 1.82, < 0.001), and to have seen a mental health professional in the past 12 months (aOR 1.28, 95% CI, 1.04 to 1.59, = 0.023).
Cannabis use in the past 30 days was associated with suicidal thinking and depression in adults. This relationship is likely multifactorial but highlights the need for specific guidelines and policies for the prescription of medical cannabis for psychiatric therapy. Future research should continue to characterize the health effects of cannabis use in the general population.
随着大麻使用的日益普及，人们越来越关注大麻使用与抑郁和自杀意念之间的关系。本研究旨在使用全国代表性数据评估近期大麻使用与自杀意念之间的关系。
使用 2005 年至 2018 年国家健康和营养调查的数据进行横断面分析。参与者根据他们是否在过去 30 天内使用过大麻分为两组。主要结局是自杀意念，次要结局是抑郁和最近看过心理健康专业人员。采用多因素逻辑回归调整潜在混杂因素，并在模型中考虑了调查样本权重。
与无近期使用大麻者（n=18599）相比，近期使用大麻者（n=3127）在过去 2 周内更有可能出现自杀意念（调整后的优势比[OR]1.54，95%置信区间[CI]1.19 至 2.00，p=0.001）、抑郁（调整后的 OR 1.53，95% CI 1.29 至 1.82，p<0.001），以及在过去 12 个月内看过心理健康专业人员（调整后的 OR 1.28，95% CI 1.04 至 1.59，p=0.023）。
过去 30 天内使用大麻与成年人的自杀意念和抑郁有关。这种关系可能是多因素的，但强调了为精神治疗开具医用大麻处方制定具体指南和政策的必要性。未来的研究应继续描述普通人群中使用大麻对健康的影响。
