From the Division of Rheumatology, Department of Internal Medicine, University of Health Sciences Gulhane Medicine Faculty.
Ankara University Faculty of Medicine, Department of Biostatistics.
J Clin Rheumatol. 2022 Jan 1;28(1):e161-e165. doi: 10.1097/RHU.0000000000001669.
Sarcopenia is a progressive and generalized loss of muscle mass and function. The aim of this study was to evaluate the frequency of sarcopenia among patients with primary Sjögren's syndrome (SS) and the factors related with sarcopenia.
Forty-four female patients with primary SS and 44 female control subjects were included in this cross-sectional study between February and August 2019. Sarcopenia was evaluated by the handgrip test, Skeletal Muscle Mass Index, and gait speed test.
Eleven patients (25.0%) had presarcopenia in the SS group and 2 (4.5%) in the control group (p = 0.007). Compared with control subjects, SS patients had lower results of hand grip and gait speed tests (p = 0.005 and p < 0.001, respectively). According to the Mini Nutritional Assessment Short Form, patients with presarcopenia had higher risk of malnutrition compared with patients without sarcopenia (p = 0.043). Patients with presarcopenia had higher scores in the European League Against Rheumatism Sjögren's Syndrome Patient-Reported Index pain domain and patient visual analog scale for global disease activity compared with patients without sarcopenia (p = 0.044 and p = 0.036, respectively). In multivariate regression analysis, European League Against Rheumatism Sjögren's Syndrome Patient-Reported Index pain was associated with hand grip strength (p = 0.016, R2 = 0.13) and Mini Nutritional Assessment Short Form was associated with Skeletal Muscle Mass Index (p = 0.005).
Risk of sarcopenia is increased in patients with SS. Pain and malnutrition may contribute to presarcopenia. Evaluating pain and patient's global disease activity may help physicians to determine patients with increased risk of sarcopenia. Controlling disease activity and pain and preventing malnutrition may reduce the risk of development of sarcopenia.
肌少症是一种进行性和全身性的肌肉质量和功能丧失。本研究旨在评估原发性干燥综合征（SS）患者中肌少症的频率以及与肌少症相关的因素。
本横断面研究纳入了 2019 年 2 月至 8 月间的 44 例原发性 SS 女性患者和 44 例女性对照组。通过握力测试、骨骼肌质量指数和步态速度测试评估肌少症。
SS 组中有 11 例（25.0%）患者存在肌少症前期，对照组中有 2 例（4.5%）（p=0.007）。与对照组相比，SS 患者的握力和步态速度测试结果较低（p=0.005 和 p<0.001）。根据迷你营养评估简表，肌少症前期患者发生营养不良的风险高于无肌少症患者（p=0.043）。与无肌少症患者相比，肌少症前期患者的欧洲抗风湿病联盟干燥综合征患者报告指数疼痛域和患者整体疾病活动视觉模拟量表评分更高（p=0.044 和 p=0.036）。多元回归分析显示，欧洲抗风湿病联盟干燥综合征患者报告指数疼痛与握力强度相关（p=0.016，R2=0.13），而迷你营养评估简表与骨骼肌质量指数相关（p=0.005）。
SS 患者发生肌少症的风险增加。疼痛和营养不良可能导致肌少症前期。评估疼痛和患者的整体疾病活动可能有助于医生确定肌少症风险增加的患者。控制疾病活动和疼痛并预防营养不良可能会降低肌少症的发展风险。
