Öztürk Özgül, Feyzioğlu Özlem, Sarıtaş Fatih
Department of Physiotherapy and Rehabilitation, Acıbadem Mehmet Ali Aydınlar University, Kayışdağı St, No: 32, Ataşehir, 34752, Istanbul, Turkey.
Department of Rheumatology, Haydarpaşa Numune Research and Training Hospital, University of Health Sciences, Istanbul, Turkey.
Clin Rheumatol. 2023 Mar;42(3):783-791. doi: 10.1007/s10067-022-06427-1. Epub 2022 Nov 11.
Primary Sjögren's syndrome leads to pain and fatigue that may cause impaired muscle function and muscle mass. This study aimed to determine the presence of pre-sarcopenia and to clarify associated factors with pre-sarcopenia in primary Sjögren's syndrome patients.
This cross-sectional study recruited 49 patients with primary Sjögren's syndrome and 49 age- and gender-matched healthy controls. Sarcopenia was assessed according to European Working Group on Sarcopenia in Older People in 2018 (EGSWOP2) criteria by evaluating muscle mass, gait speed, and grip strength. Physical function was also assessed with five times sit-to-stand (FTSTS) test. Quality of life (QoL), psychological symptoms, and nutritional status were evaluated using Sarcopenia Quality of Life (SarQoL) questionnaire, Hospital Anxiety and Depression Scale (HADS), and Mini Nutritional Assessment Long Form (MNA-LF), respectively.
Pre-sarcopenia was detected in 28.5% of patients with primary Sjögren's syndrome and 6.1% of healthy controls (p = 0.006). Patients with pre-sarcopenia were older and had worse scores in terms of depression, QoL, pain scores, grip strength, and gait speed compared with those without pre-sarcopenia. The SarQoL scores and grip strength were significantly correlated with gait speed, pain, FTSTS test, and depression. Logistic regression analyses identified that the independent predictive factor for pre-sarcopenia was QoL (OR: 0.79, 95% CI: 0.65-0.95; p = 0.015).
Maintaining adequate muscle mass and muscle function in patients with primary Sjögren's syndrome may contribute toward improving health-related QoL. Also, controlling depression and malnutrition risk may help to reduce the risk of development of sarcopenia. Key Points • Pre-sarcopenia is detected in 28.4% of the patients with primary Sjögren's syndrome which is higher than healthy controls. • Pre-sarcopenia is associated with health-related quality of life in primary Sjögren's syndrome. • Psychological symptoms and low physical performance are more common in pre-sarcopenic patients.
原发性干燥综合征会导致疼痛和疲劳，可能会损害肌肉功能和肌肉量。本研究旨在确定原发性干燥综合征患者中肌肉减少症前期的存在情况，并阐明与肌肉减少症前期相关的因素。
这项横断面研究招募了49例原发性干燥综合征患者以及49例年龄和性别匹配的健康对照者。根据2018年欧洲老年人肌肉减少症工作组（EGSWOP2）标准，通过评估肌肉量、步速和握力来评估肌肉减少症。还通过五次坐立试验（FTSTS）评估身体功能。分别使用肌肉减少症生活质量（SarQoL）问卷、医院焦虑抑郁量表（HADS）和微型营养评定量表长表（MNA-LF）评估生活质量（QoL）、心理症状和营养状况。
在28.5%的原发性干燥综合征患者中检测到肌肉减少症前期，而健康对照者中的这一比例为6.1%（p = 0.006）。与没有肌肉减少症前期的患者相比，有肌肉减少症前期的患者年龄更大，在抑郁、生活质量、疼痛评分、握力和步速方面得分更低。SarQoL评分和握力与步速、疼痛、FTSTS试验和抑郁显著相关。逻辑回归分析确定，生活质量是肌肉减少症前期的独立预测因素（OR：0.79，95%CI：0.65 - 0.95；p = 0.015）。
维持原发性干燥综合征患者足够的肌肉量和肌肉功能可能有助于改善与健康相关的生活质量。此外，控制抑郁和营养不良风险可能有助于降低肌肉减少症的发生风险。要点 • 在28.4%的原发性干燥综合征患者中检测到肌肉减少症前期，这一比例高于健康对照者。• 原发性干燥综合征中肌肉减少症前期与健康相关生活质量有关。• 肌肉减少症前期患者中心理症状和身体表现较差更为常见。
