Yang Zhiwei, Yu Mingxue, Li Ganwen, Dai Xiaoling, Liu Guirong, Xie Jinjun, Li Gang, Jie Yusheng
Clin Lab. 2020 Dec 1;66(12). doi: 10.7754/Clin.Lab.2020.200623.
Coronavirus disease (COVID-19) has affected more than 100 countries worldwide and the discharge criteria of patients with COVID-19 vary across different countries. In China, patients with two negative respiratory viral RNA tests taken at least one day apart can be discharged with no further quarantine required. Currently, PCR testing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in fecal sample is not routinely performed.
We present a patient with COVID-19, whose respiratory swabs became negative but fecal sample remained positive for SARS-CoV-2 RNA.
Stool sample collected on 27th of February was still positive for SARS-CoV-2 RNA, 24 days after the first negative respiratory swab.
Based on the experience from the 2003 SARS epidemic, we recommend that fecal RNA testing of SARS-CoV-2 should be incorporated into the discharge criteria to minimize the risk of transmission from the gastrointestinal tract.
冠状病毒病（COVID-19）已在全球100多个国家造成影响，不同国家的COVID-19患者出院标准各不相同。在中国，间隔至少一天进行的两次呼吸道病毒RNA检测均为阴性的患者可以出院，无需进一步隔离。目前，粪便样本中严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的PCR检测并非常规操作。
我们报告了一名COVID-19患者，其呼吸道拭子检测结果转为阴性，但粪便样本中SARS-CoV-2 RNA仍呈阳性。
2月27日采集的粪便样本中，SARS-CoV-2 RNA仍为阳性，此时距离首次呼吸道拭子检测结果呈阴性已过去24天。
基于2003年非典疫情的经验，我们建议将SARS-CoV-2粪便RNA检测纳入出院标准，以尽量降低胃肠道传播风险。
