Central Research LaboratoryBeijing Center for Disease Preventive Medical Research, Beijing 100013, China.
Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing 100013, China.
Bioconjug Chem. 2021 Jan 20;32(1):161-171. doi: 10.1021/acs.bioconjchem.0c00594. Epub 2020 Dec 18.
Early identification and treatment of breast cancer is very important for breast conserving therapy and to improve the prognosis and survival rates of patients. Multifunctional nanotheranostic agents are of particular importance in the field of precise nanomedicine, since they can augment the visualization and treatment of cancer. We developed a novel BiS nanoparticle coated with a hyaluronic acid (HA)-modified tantalum oxide (TaO) nanoshell (BiS@TaO-HA). The as-prepared core/shell nanoparticles exhibited a high BiS nanoparticle loading efficiency of (67 wt %). The TaO nanoshell exhibited excellent biocompatibility and computed tomography imaging capacity, and the BiS nanoparticles exhibited an excellent photothermal transducing performance and computed tomography (CT) and photoacoustic imaging capacity. As a result of these merits, the BiS@TaO core-shell nanoparticles can act as a theranostic agent for CT/photoacoustically monitored enhanced photothermal therapy. These findings will evoke new interest in future cancer therapeutic strategies based on biocompatible functional nanomaterials.
早期发现和治疗乳腺癌对于保乳治疗以及提高患者的预后和生存率非常重要。多功能纳米诊疗剂在精准纳米医学领域具有特别重要的意义，因为它们可以增强癌症的可视化和治疗效果。我们开发了一种新型的 BiS 纳米粒子，其表面包覆有透明质酸（HA）修饰的氧化钽（TaO）纳米壳（BiS@TaO-HA）。所制备的核/壳纳米粒子具有很高的 BiS 纳米粒子负载效率（67wt%）。TaO 纳米壳具有优异的生物相容性和计算机断层扫描（CT）成像能力，而 BiS 纳米粒子则具有优异的光热转换性能和 CT 和光声成像能力。由于这些优点，BiS@TaO 核壳纳米粒子可以作为一种用于 CT/光声监测增强光热治疗的治疗诊断一体化试剂。这些发现将激发人们对基于生物相容性功能纳米材料的未来癌症治疗策略的新兴趣。
