Department of Biomedicine & Prevention, Genetics Section, University of Rome Tor Vergata, Rome 00133, Italy.
UniCamillus - Saint Camillus International University of Health Sciences, Rome 00131, Italy.
Epigenomics. 2021 Jan;13(1):5-13. doi: 10.2217/epi-2020-0278. Epub 2020 Dec 18.
To evaluate genetic and expression variability of three miRNAs potentially involved in systemic lupus erythematosus (SLE) and to identify any miRNA's target gene. Gene polymorphisms and expression levels of three miRNAs have been evaluated in a cohort of SLE patients and controls. miR-142 and miR-499a were significantly down-expressed in patients (p = 0.005 and p = 0.02, respectively). A trend for down-expression of miR-155 was also observed (p = 0.07). The lower expression of miR-142 was associated with the rs2632516 polymorphism variant allele (p = 0.002). Predictive analyses identified a target gene common to the three miRNAs, , whose higher expression was seen in patients compared with controls (p = 0.03). The three miRNAs and MDM2 might be involved in SLE.
评估三种可能与系统性红斑狼疮（SLE）相关的 miRNA 的遗传和表达变异性，并鉴定任何 miRNA 的靶基因。 在一组 SLE 患者和对照组中评估了三种 miRNA 的基因多态性和表达水平。miR-142 和 miR-499a 在患者中表达明显下调（p = 0.005 和 p = 0.02）。miR-155 的表达也呈下调趋势（p = 0.07）。miR-142 的低表达与 rs2632516 多态性变体等位基因相关（p = 0.002）。预测分析鉴定了三个 miRNA 的共同靶基因 ，其在患者中的表达高于对照组（p = 0.03）。这三种 miRNA 和 MDM2 可能参与了 SLE。
