Department of Medicine, Division of Cardiology, Emory University, Atlanta, Georgia.
Am J Physiol Heart Circ Physiol. 2021 Feb 1;320(2):H734-H739. doi: 10.1152/ajpheart.00518.2020. Epub 2020 Dec 18.
The integrin family, an indispensable part of cell-cell and cell-matrix interactions, consists of a group of heterodimeric adhesion receptors formed by α- and β-integrin subunits. Their wide expression and unique bidirectional signaling pathways allow them to play roles in a variety of biological activities including blood clot formation, cell attachment, and migration. Evidence suggests that integrins are essential regulators of the initiation of acute inflammation, especially two key aspects of this process i.e., vascular permeability and leukocyte recruitment. This mini-review discusses the importance of integrins at the onset of the acute inflammatory response and outlines research advances regarding the function of integrins and their modulators at different stages of this process. Insights into the fine-tuning of integrin signaling during acute inflammation may inspire the design of new drugs for inflammatory diseases.
整合素家族是细胞-细胞和细胞-基质相互作用不可或缺的一部分，由一组由α和β整合素亚基组成的异二聚体粘附受体组成。它们广泛的表达和独特的双向信号通路使其能够在多种生物活性中发挥作用，包括血栓形成、细胞黏附和迁移。有证据表明，整合素是急性炎症起始的重要调节剂，特别是该过程的两个关键方面，即血管通透性和白细胞募集。本篇综述讨论了整合素在急性炎症反应起始中的重要性，并概述了关于整合素及其调节剂在该过程不同阶段的功能的研究进展。深入了解急性炎症期间整合素信号的精细调控可能会激发针对炎症性疾病的新药设计。
