Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
Social Administrative Pharmacy Division, Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
PLoS One. 2020 Dec 18;15(12):e0243934. doi: 10.1371/journal.pone.0243934. eCollection 2020.
Although the clinical benefits of medical genetic testing have been proven, there has been limited evidence on its economic impact in Thai setting. Thus, this study aimed to evaluate the economic impact of genetic testing services provided by the Center for Medical Genomics (CMG) in Thailand.
Cost-benefit analysis was conducted from provider and societal perspectives. Cost and output data of genetic testing services provided by the CMG during 2014 to 2018 and published literature reviews were applied to estimate the costs and benefits. Monetary benefits related to genetic testing services were derived through human capital approach.
The total operation cost was 126 million baht over five years with an average annual cost of 21 million baht per year. The net benefit, benefit-to-cost ratio, and return on investment were 5,477 million baht, 43 times, and 42 times, respectively. Productivity gain was the highest proportion (50.57%) of the total benefit.
The provision of genetic testing services at the CMG gained much more benefits than the cost. This study highlighted a good value for money in the establishment of medical genomics settings in Thailand and other developing countries.
尽管医学遗传检测的临床益处已得到证实，但在泰国的经济影响方面，证据有限。因此，本研究旨在评估泰国医学基因组中心（CMG）提供的基因检测服务的经济影响。
从提供者和社会角度进行成本效益分析。CMG 在 2014 年至 2018 年期间提供的基因检测服务的成本和产出数据以及已发表的文献综述被用于估算成本和效益。与基因检测服务相关的货币效益是通过人力资本方法得出的。
五年的总运营成本为 1.26 亿泰铢，平均每年为 2100 万泰铢。净效益、效益成本比和投资回报率分别为 54.77 亿泰铢、43 倍和 42 倍。生产力收益是总收益中最高的部分（50.57%）。
CMG 提供基因检测服务的收益远远超过成本。本研究强调了在泰国和其他发展中国家建立医学基因组学环境的良好成本效益。
