二硒化物对埃及伊蚊（双翅目：蚊科）幼虫的选择性活性。
Selective activity of diselenides against Aedes aegypti (Diptera: Culicidae) larvae.
机构信息
Universidade Federal de Mato Grosso, Departamento de Botânica e Ecologia, Cuiabá, MT, Brasil.
Universidade Federal de Mato Grosso, Faculdade de Engenharia, Cuiabá, MT, Brasil.
出版信息
Rev Soc Bras Med Trop. 2020 Dec 21;54:e20200146. doi: 10.1590/0037-8682-0146-2020. eCollection 2020.
INTRODUCTION
Aedes aegypti (L.) is the major vector of arboviruses that causes serious public health concerns in tropical and subtropical countries.
METHODS
We examined the larvicidal activity of 1,2-diphenyldiselenide [(PhSe)2] and 1,2-bis(4-chlorophenyl) diselenide [(p-ClPhSe)2] and determine its toxicity to different non-target organisms.
RESULTS
(PhSe)2 and (p-ClPhSe)2 killed Ae. aegypti L3 larvae with LC50/24h values of 65.63 µM (20.48 mg/L) and 355.19 µM (135.33 mg/L), respectively. (PhSe)2 was not toxic to the four model organisms.
CONCLUSIONS
(PhSe)2 is a larvicidal compound with selective action against Ae. aegypti larvae. The mechanisms of action of (PhSe)2 under field conditions remain to be investigated.
简介
埃及伊蚊（Aedes aegypti（L.））是引起热带和亚热带国家严重公共卫生问题的虫媒病毒的主要载体。
方法
我们研究了 1,2-二苯二硒醚[(PhSe)2]和 1,2-双(4-氯苯基)二硒醚[(p-ClPhSe)2]对幼虫的杀幼虫活性，并确定其对不同非靶标生物的毒性。
结果
(PhSe)2 和 (p-ClPhSe)2 杀死埃及伊蚊 L3 幼虫的 LC50/24h 值分别为 65.63 µM（20.48 mg/L）和 355.19 µM（135.33 mg/L）。(PhSe)2 对四种模式生物没有毒性。
结论
(PhSe)2 是一种对埃及伊蚊幼虫具有选择性作用的杀幼虫化合物。(PhSe)2 在田间条件下的作用机制仍有待研究。
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