Universidade Federal de Mato Grosso, Departamento de Botânica e Ecologia, Cuiabá, MT, Brasil.
Universidade Federal de Mato Grosso, Faculdade de Engenharia, Cuiabá, MT, Brasil.
Rev Soc Bras Med Trop. 2020 Dec 21;54:e20200146. doi: 10.1590/0037-8682-0146-2020. eCollection 2020.
Aedes aegypti (L.) is the major vector of arboviruses that causes serious public health concerns in tropical and subtropical countries.
We examined the larvicidal activity of 1,2-diphenyldiselenide [(PhSe)2] and 1,2-bis(4-chlorophenyl) diselenide [(p-ClPhSe)2] and determine its toxicity to different non-target organisms.
(PhSe)2 and (p-ClPhSe)2 killed Ae. aegypti L3 larvae with LC50/24h values of 65.63 µM (20.48 mg/L) and 355.19 µM (135.33 mg/L), respectively. (PhSe)2 was not toxic to the four model organisms.
(PhSe)2 is a larvicidal compound with selective action against Ae. aegypti larvae. The mechanisms of action of (PhSe)2 under field conditions remain to be investigated.
埃及伊蚊（Aedes aegypti（L.））是引起热带和亚热带国家严重公共卫生问题的虫媒病毒的主要载体。
我们研究了 1,2-二苯二硒醚[(PhSe)2]和 1,2-双(4-氯苯基)二硒醚[(p-ClPhSe)2]对幼虫的杀幼虫活性，并确定其对不同非靶标生物的毒性。
(PhSe)2 和 (p-ClPhSe)2 杀死埃及伊蚊 L3 幼虫的 LC50/24h 值分别为 65.63 µM（20.48 mg/L）和 355.19 µM（135.33 mg/L）。(PhSe)2 对四种模式生物没有毒性。
(PhSe)2 是一种对埃及伊蚊幼虫具有选择性作用的杀幼虫化合物。(PhSe)2 在田间条件下的作用机制仍有待研究。
