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实现转化研究中有效数据管理的途径。

Road to effective data curation for translational research.

机构信息

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg; ELIXIR Luxembourg, Esch-sur-Alzette, Luxembourg.

GlaxoSmithKline Pharma GmbH, Hertfordshire, UK.

出版信息

Drug Discov Today. 2021 Mar;26(3):626-630. doi: 10.1016/j.drudis.2020.12.007. Epub 2020 Dec 15.

Abstract

Translational research today is data-intensive and requires multi-stakeholder collaborations to generate and pool data together for integrated analysis. This leads to the challenge of harmonization of data from different sources with different formats and standards, which is often overlooked during project planning and thus becomes a bottleneck of the research progress. We report on our experience and lessons learnt about data curation for translational research garnered over the course of the European Translational Research Infrastructure & Knowledge management Services (eTRIKS) program (https://www.etriks.org), a unique, 5-year, cross-organizational, cross-cultural collaboration project funded by the Innovative Medicines Initiative of the EU. Here, we discuss the obstacles and suggest what steps are needed for effective data curation in translational research, especially for projects involving multiple organizations from academia and industry.

摘要

转化研究如今是一个数据密集型的领域,需要多方利益相关者的合作,以便将数据汇集在一起进行综合分析。这就带来了一个挑战,即需要协调来自不同来源、具有不同格式和标准的数据,而这往往在项目规划阶段被忽视,从而成为研究进展的瓶颈。我们报告了在欧洲转化研究基础设施和知识管理服务(eTRIKS)计划(https://www.etriks.org)期间积累的关于转化研究数据管理的经验和教训,该计划是一个独特的、为期 5 年的跨组织、跨文化合作项目,由欧盟的创新药物倡议资助。在这里,我们讨论了障碍,并提出了在转化研究中进行有效数据管理所需的步骤,特别是对于涉及学术界和工业界的多个组织的项目。

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