School of Nursing, Yangzhou University, Yangzhou, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Jiangsu Key Laboratory of Zoonosis, Yangzhou University, China.
School of Nursing, Yangzhou University, Yangzhou, China.
Gen Hosp Psychiatry. 2021 Jan-Feb;68:59-64. doi: 10.1016/j.genhosppsych.2020.11.010. Epub 2020 Nov 30.
Oxidative stress is considered a possible mechanism of irritable bowel syndrome (IBS) and depression. This study determined the possible association of serum peroxiredoxin 1 (PRDX1; a key antioxidant enzyme) and brain-derived neurotrophic factor (BDNF) with anxiety and depression symptoms in IBS patients.
According to the Rome IV diagnostic criteria, 177 IBS patients from February 2019 to July 2019 were included. Serum levels of PRDX1, BDNF, and TNFα were detected by enzyme-linked immunosorbent assay. Levels of anxiety and depression were assessed with the Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS).
Compared with normal IBS patients, patients with anxiety and depression symptoms had significantly higher serum PRDX1 (p<0.001; p=0.002) and TNFα (p<0.001; p = 0.002) and significantly lower BDNF (p < 0.001; p = 0.002). Serum PRDX1 (r = 0.659, p < 0.001; r = 0.466, p < 0.001) and TNFα (r = 0.531, p < 0.001; r = 0.449, p < 0.001) were positively correlated with SAS and SDS, respectively, whereas BDNF was negatively correlated with SAS (r = 0.594, p < 0.001) and SDS (r = 0.534, p < 0.001). Multivariable regression analysis revealed that IBS severity, BDNF, and PRDX1 were significant predictors of anxiety. BDNF was also a significant predictor of depression.
Elevated PRDX1 and decreased BDNF in serum may be closely related to psychological symptoms in IBS. Results of this study suggested that PRDX1 may be an important target for IBS treatment in fighting against intestinal and psychological symptoms.
氧化应激被认为是肠易激综合征（IBS）和抑郁症的可能发病机制。本研究旨在确定血清过氧化物还原酶 1（PRDX1；一种关键的抗氧化酶）和脑源性神经营养因子（BDNF）与 IBS 患者焦虑和抑郁症状的可能相关性。
根据罗马 IV 诊断标准，纳入 2019 年 2 月至 7 月期间的 177 例 IBS 患者。采用酶联免疫吸附试验检测 PRDX1、BDNF 和 TNFα 的血清水平。采用焦虑自评量表（SAS）和抑郁自评量表（SDS）评估焦虑和抑郁程度。
与正常 IBS 患者相比，伴焦虑和抑郁症状的患者血清 PRDX1（p<0.001;p=0.002）和 TNFα（p<0.001;p=0.002）显著升高，BDNF 显著降低（p<0.001;p=0.002）。血清 PRDX1（r=0.659，p<0.001；r=0.466，p<0.001）和 TNFα（r=0.531，p<0.001；r=0.449，p<0.001）与 SAS 和 SDS 分别呈正相关，而 BDNF 与 SAS（r=0.594，p<0.001）和 SDS（r=0.534，p<0.001）呈负相关。多变量回归分析显示，IBS 严重程度、BDNF 和 PRDX1 是焦虑的显著预测因子。BDNF 也是抑郁的显著预测因子。
血清中 PRDX1 升高和 BDNF 降低可能与 IBS 的心理症状密切相关。本研究结果表明，PRDX1 可能是治疗 IBS 对抗肠道和心理症状的重要靶点。
