12265University of Maryland, School of Nursing, Baltimore, MD, USA.
National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA.
Biol Res Nurs. 2021 Apr;23(2):231-237. doi: 10.1177/1099800420948589. Epub 2020 Aug 18.
Irritable bowel syndrome (IBS) is a chronic gastrointestinal condition predominantly affecting the female sex, and is characterized by brain-gut axis dysregulation. Relevance of hormones along the hypothalamic-pituitary gonadal axis and hypothalamic-pituitary adrenal axis to IBS symptomatology remain unclear, as does the significance of other modulators including brain derived neurotrophic factor (BDNF), leptin, and transforming growth factor βeta 1 (TGF-β1).
Females with IBS were compared with female healthy controls (HC) on age, race, hormonal contraceptive use, body mass index, adrenocorticotropic hormone, cortisol, estradiol, follicular stimulating hormone, luteinizing hormone, progesterone, total cholesterol, Center for Epidemiological Studies Depression Scale (CES-D) and Perceived Stress Scale (PSS). BDNF, leptin, and TGF-β1 were quantified using enzyme-linked immunosorbent assay. Descriptive statistics, non-parametric techniques, and regression analyses were performed.
Participants with IBS (n = 12) displayed higher estradiol ( = .027) than did HC (n = 21). Direction of associations among study variables often differed between groups: BDNF and progesterone in HC (r = .623) and in IBS (r = -.723). The relationship between log (CES-D) and log (estradiol) varied by IBS status (interaction term = 0.019).
Elevated estradiol in participants with IBS, and differential patterns of biological and psychological indices between groups, encourages further inquiry on the relevance of sex hormones, BDNF, leptin, and TGF-β1 to symptoms of IBS. Future research endeavors should conduct longitudinal quantification of sex hormones with subjective symptom assessment to facilitate insight on the pathophysiology and female sex bias in IBS.
肠易激综合征（IBS）是一种主要影响女性的慢性胃肠道疾病，其特征是脑-肠轴失调。沿着下丘脑-垂体性腺轴和下丘脑-垂体肾上腺轴的激素与 IBS 症状的相关性尚不清楚，其他调节剂的意义也不清楚，包括脑源性神经营养因子（BDNF）、瘦素和转化生长因子βeta1（TGF-β1）。
将 IBS 女性与女性健康对照（HC）进行比较，比较项目包括年龄、种族、激素避孕使用情况、体重指数、促肾上腺皮质激素、皮质醇、雌二醇、卵泡刺激素、黄体生成素、孕酮、总胆固醇、流行病学研究中心抑郁量表（CES-D）和感知压力量表（PSS）。使用酶联免疫吸附测定法定量测定 BDNF、瘦素和 TGF-β1。进行描述性统计、非参数技术和回归分析。
IBS 组（n = 12）参与者的雌二醇水平高于 HC 组（n = 21）（ =.027）。研究变量之间的关联方向在组间往往不同：HC 组中 BDNF 和孕酮（r =.623）和 IBS 组中 BDNF 和孕酮（r = -.723）。log（CES-D）和 log（雌二醇）之间的关系因 IBS 状态而异（交互项 = 0.019）。
IBS 组参与者的雌二醇水平升高，以及组间生物和心理指标的差异模式，鼓励进一步探究性激素、BDNF、瘦素和 TGF-β1 与 IBS 症状的相关性。未来的研究工作应进行性激素的纵向定量分析，并结合主观症状评估，以促进对 IBS 病理生理学和女性性别偏见的深入了解。
