Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA.
Cells. 2020 Dec 16;9(12):2699. doi: 10.3390/cells9122699.
The immune system plays a critical role during pregnancy, but the specific mechanisms and immune cell function needed to support pregnancy remain incompletely understood. Despite decades of research efforts, it is still unclear how the immune system maintains tolerance of fetal-derived tissues, which include most cells of the placenta and of course the fetus itself, without forfeiting the ability to protect against harmful infections. T cells recognize antigen in the context of major histocompatibility complex (MHC) encoded proteins, but classical MHC class I and II expression are diminished in fetal-derived cells. Can T cells present at the maternal-fetal interface (MFI) protect these cells from infection? Here we review what is known in regard to tissue-resident memory T (Trm) cells at the MFI. We mainly focus on how Trm cells can contribute to protection in the context of the unique features of the MFI, such as limited MHC expression as well as the temporary nature of the MFI, that are not found in other tissues.
免疫系统在怀孕期间起着至关重要的作用，但支持妊娠所需的特定机制和免疫细胞功能仍不完全清楚。尽管经过几十年的研究努力，人们仍然不清楚免疫系统如何在不丧失抵御有害感染能力的情况下，对胎儿来源的组织（包括胎盘的大多数细胞，当然还有胎儿本身）保持耐受。T 细胞在主要组织相容性复合体 (MHC) 编码蛋白的背景下识别抗原，但经典 MHC 类 I 和 II 的表达在胎儿来源的细胞中减少。在母体-胎儿界面 (MFI) 存在的 T 细胞能否保护这些细胞免受感染？在这里，我们回顾了在 MFI 处组织驻留记忆 T (Trm) 细胞的已知内容。我们主要关注 Trm 细胞如何在 MFI 的独特特征（例如 MHC 表达有限以及 MFI 的暂时性）的背景下为保护做出贡献，这些特征在其他组织中不存在。
