Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, 310 Cedar Street, LSOG 309A, New Haven, CT 06510, USA.
Division of Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, 310 Cedar Street, LSOG 305C, New Haven, CT 06510, USA.
Obstet Gynecol Clin North Am. 2020 Mar;47(1):49-63. doi: 10.1016/j.ogc.2019.10.006.
In this article, the authors provide a general overview of the major immune cells present at the maternal-fetal interface, describe the key mechanisms used by the placenta to promote maternal immune regulation, tolerance, and adaptation, and discuss how dysregulation of these pathways could lead to obstetric complications such as pregnancy loss and preeclampsia. Finally, they conclude with a description of the innate immune properties of the human placenta that not only serve to protect the pregnancy from infection but also contribute to pregnancy complications such as preterm birth.
本文作者概述了存在于母体-胎儿界面的主要免疫细胞，描述了胎盘用于促进母体免疫调节、耐受和适应的关键机制，并讨论了这些途径的失调如何导致产科并发症，如妊娠丢失和子痫前期。最后，他们描述了人类胎盘的固有免疫特性，这些特性不仅有助于保护妊娠免受感染，而且还导致早产等妊娠并发症。
