Chaer Rayane, Nakouzi Nour, Itani Leila, Tannir Hana, Kreidieh Dima, El Masri Dana, El Ghoch Marwan
Department of Nutrition and Dietetics, Faculty of Health Sciences, Beirut Arab University, P.O. Box 11-5020 Riad El Solh, Beirut 11072809, Lebanon.
Diseases. 2020 Dec 16;8(4):46. doi: 10.3390/diseases8040046.
Reproductive health is compromised during anorexia nervosa (AN). However, it is still unclear whether this medical complication is reversible after recovery from AN. The purpose of this paper was to conduct a systematic review of the major reproductive health outcomes in females after recovery from AN. The review was conducted in adherence to preferred reporting items for systematic review and meta-analyses (PRISMA) guidelines. Data were collated using meta-analysis and a narrative approach. Of the 1186 articles retrieved, five studies met the inclusion criteria and were reviewed. These studies monitored weight-restored females who had recovered from AN for a follow-up period of between six and 18 years. Their narrative analysis revealed that appropriate treatment of AN leads to the normalization of reproductive function, especially in terms of fertility, pregnancy, and childbirth rates. The meta-analysis confirmed this finding, where the pooled odds of childbirth rates between the AN group and the general population was not statistically significant (OR = 0.75, 95% CI: 0.43-1.29, = 0.41). We conclude that if patients undergo appropriate eating-disorder treatment and weight restoration, it appears to be unlikely that reproductive health is affected by AN. However, since this finding is derived from only a few studies, it requires replication and confirmation.
神经性厌食症（AN）期间生殖健康会受到损害。然而，目前仍不清楚这种医学并发症在从AN康复后是否可逆。本文的目的是对女性从AN康复后的主要生殖健康结果进行系统综述。该综述是按照系统综述和荟萃分析的首选报告项目（PRISMA）指南进行的。使用荟萃分析和叙述性方法整理数据。在检索到的1186篇文章中，有五项研究符合纳入标准并进行了综述。这些研究对从AN康复且体重恢复的女性进行了为期6至18年的随访监测。他们的叙述性分析表明，对AN进行适当治疗可使生殖功能恢复正常，尤其是在生育能力、妊娠率和分娩率方面。荟萃分析证实了这一发现，AN组和一般人群之间分娩率的合并比值没有统计学意义（OR = 0.75，95% CI：0.43 - 1.29，P = 0.41）。我们得出结论，如果患者接受适当的饮食失调治疗并恢复体重，生殖健康似乎不太可能受到AN的影响。然而，由于这一发现仅来自少数研究，需要重复和证实。
