Professor of Neurology, Wayne State University School of Medicine, Detroit, MI.
J Stroke Cerebrovasc Dis. 2021 Sep;30(9):105541. doi: 10.1016/j.jstrokecerebrovasdis.2020.105541. Epub 2020 Dec 16.
The brain and kidney both uniquely are highly susceptible to vascular injury from shared vascular risk factors. However these are not sufficient to explain the complete extent of cerebrovascular disease especially small vessel disease in its myriad presentations that patients with chronic kidney disease manifest. They both require a large amount of blood supply to function optimally. Shared anatomical and physiological factors such as the presence of strain vessels, the local vascular autoregulation that control blood supply possible, results in the vulnerability of these organs to the vascular risk factors. Because it is a bidirectional system where each affects the other, it is best considered as a cerebro-renal unit.
大脑和肾脏都极易受到血管损伤的影响，这些损伤是由共同的血管风险因素引起的。然而，这些因素并不能完全解释脑血管疾病的发生，特别是慢性肾脏病患者所表现出的多种小血管疾病。它们都需要大量的血液供应才能发挥最佳功能。共同的解剖学和生理学因素，如应变血管的存在、控制血液供应的局部血管自动调节，使这些器官容易受到血管风险因素的影响。由于这是一个相互影响的双向系统，因此最好将其视为一个脑肾单元。
