乳腺癌患者肝转移的组织病理学生长模式与肝切除术后生存率之间的关联。
Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients.
作者信息
Bohlok Ali, Vermeulen Peter, Leduc Sophia, Latacz Emily, Botzenhart Lara, Richard François, De Schepper Maxim, Geukens Tatjana, Lucidi Valerio, Ignatiadis Michail, Aftimos Philippe, Sotiriou Christos, Piccart Martine, Hendlisz Alain, Van Laere Steven, Dirix Luc, Noël Jean-Christophe, Biganzoli Elia, Larsimont Denis, Desmedt Christine, Donckier Vincent
机构信息
Department of Surgery, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
Translational Cancer Research Unit, GZA Hospitals & CORE, MIPRO, University of Antwerp, Antwerp, Belgium.
出版信息
NPJ Breast Cancer. 2020 Dec 18;6(1):64. doi: 10.1038/s41523-020-00209-1.
Currently, there are no markers to identify patients with liver-only or liver-dominant metastases that would benefit from hepatic surgery. Here we characterized histopathological growth patterns (HGPs) of liver metastases in a consecutive series of 36 breast cancer patients who underwent hepatic surgery. Survival analyses showed that the presence of a desmoplastic HGP in the liver metastases (a rim of fibrous tissue separating cancer cells from the liver parenchyma, present in 20 (56%) patients) is independently associated with favorable progression-free and overall survival when compared with the replacement HGP (cancer cells growing into the liver parenchyma, present in 16 (44%) patients).
目前，尚无标志物可用于识别仅发生肝转移或肝转移为主且能从肝脏手术中获益的患者。在此，我们对连续36例接受肝脏手术的乳腺癌患者肝转移灶的组织病理学生长模式（HGPs）进行了特征分析。生存分析表明，与替代生长模式（癌细胞向肝实质内生长，16例（44%）患者存在）相比，肝转移灶中存在促结缔组织增生性生长模式（纤维组织边缘将癌细胞与肝实质分隔开，20例（56%）患者存在）与无进展生存期和总生存期良好独立相关。
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