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Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets.

作者信息

Singh Dhiraj Kumar, Singh Bindu, Ganatra Shashank R, Gazi Michal, Cole Journey, Thippeshappa Rajesh, Alfson Kendra J, Clemmons Elizabeth, Gonzalez Olga, Escobedo Ruby, Lee Tae-Hyung, Chatterjee Ayan, Goez-Gazi Yenny, Sharan Riti, Gough Maya, Alvarez Cynthia, Blakley Alyssa, Ferdin Justin, Bartley Carmen, Staples Hilary, Parodi Laura, Callery Jessica, Mannino Amanda, Klaffke Benjamin, Escareno Priscilla, Platt Roy N, Hodara Vida, Scordo Julia, Gautam Shalini, Vilanova Andreu G, Olmo-Fontanez Angelica, Schami Alyssa, Oyejide Adelekan, Ajithdoss Dharani K, Copin Richard, Baum Alina, Kyratsous Christos, Alvarez Xavier, Ahmed Mushtaq, Rosa Bruce, Goodroe Anna, Dutton John, Hall-Ursone Shannan, Frost Patrice A, Voges Andra K, Ross Corinna N, Sayers Ken, Chen Christopher, Hallam Cory, Khader Shabaana A, Mitreva Makedonka, Anderson Timothy J C, Martinez-Sobrido Luis, Patterson Jean L, Turner Joanne, Torrelles Jordi B, Dick Edward J, Brasky Kathleen, Schlesinger Larry S, Giavedoni Luis D, Carrion Ricardo, Kaushal Deepak

机构信息

Southwest National Primate Research Center, San Antonio, TX, USA.

Texas Biomedical Research Institute, San Antonio, TX, USA.

出版信息

Nat Microbiol. 2021 Jan;6(1):73-86. doi: 10.1038/s41564-020-00841-4. Epub 2020 Dec 18.

DOI:10.1038/s41564-020-00841-4
PMID:33340034
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7890948/
Abstract

Non-human primate models will expedite therapeutics and vaccines for coronavirus disease 2019 (COVID-19) to clinical trials. Here, we compare acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in young and old rhesus macaques, baboons and old marmosets. Macaques had clinical signs of viral infection, mild to moderate pneumonitis and extra-pulmonary pathologies, and both age groups recovered in two weeks. Baboons had prolonged viral RNA shedding and substantially more lung inflammation compared with macaques. Inflammation in bronchoalveolar lavage was increased in old versus young baboons. Using techniques including computed tomography imaging, immunophenotyping, and alveolar/peripheral cytokine response and immunohistochemical analyses, we delineated cellular immune responses to SARS-CoV-2 infection in macaque and baboon lungs, including innate and adaptive immune cells and a prominent type-I interferon response. Macaques developed T-cell memory phenotypes/responses and bystander cytokine production. Old macaques had lower titres of SARS-CoV-2-specific IgG antibody levels compared with young macaques. Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/88e910fdf00c/nihms-1649317-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/fa656250f49b/nihms-1649317-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/2d345805f336/nihms-1649317-f0008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/5a4918286f4f/nihms-1649317-f0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/087bce7f095b/nihms-1649317-f0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/642e482aceb7/nihms-1649317-f0013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/ead21c93fc7c/nihms-1649317-f0002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/2d345805f336/nihms-1649317-f0008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/6af4c41acbdf/nihms-1649317-f0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/5a4918286f4f/nihms-1649317-f0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/087bce7f095b/nihms-1649317-f0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/642e482aceb7/nihms-1649317-f0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/07568d280c5b/nihms-1649317-f0014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/2733ee86df20/nihms-1649317-f0015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/ba6b0143e2aa/nihms-1649317-f0016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/20d305828024/nihms-1649317-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/ead21c93fc7c/nihms-1649317-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/8e73a4468c72/nihms-1649317-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/f8cc6e6462d0/nihms-1649317-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/310a407e83fa/nihms-1649317-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e511/7890948/88e910fdf00c/nihms-1649317-f0006.jpg

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本文引用的文献

[1]
IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection.

Commun Biol. 2021-3-5

[2]
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The COVID-19 Pandemic during the Time of the Diabetes Pandemic: Likely Fraternal Twins?

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Science. 2020-5-20

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Science. 2020-5-20

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