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孤立性唇皮炎(特应性唇炎),外用他克莫司 0.03 治疗有效。

Isolated lip dermatitis (atopic cheilitis), successfully treated with topical tacrolimus 0.03.

机构信息

Oral medicine center  4 Fokaias STR, 14232, N.Ionia  Athens, Greece

出版信息

Med Oral Patol Oral Cir Bucal. 2021 May 1;26(3):e357-e360. doi: 10.4317/medoral.24230.

DOI:10.4317/medoral.24230
PMID:33340078
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8141307/
Abstract

BACKGROUND

Exfoliative and erosive cheilitis, may be a source of speech and chewing discomfort, but may also be an aesthetic issue for the patients affected. Such a clinical presentation may implicate a variety of inflammatory conditions, including atopic (eczematous) cheilitis. Topical and systemic agents, e.g. corticosteroids, have been used to treat inflammatory lip conditions. Topical tacrolimus has also been used in some inflammatory lip conditions.

MATERIAL AND METHODS

We performed a retrospective clinical analysis of atopic cheilitis patients.

RESULTS

Between 2015 and 2020, we addressed 7 (seven) patients with atopic dermatitis affecting only lips and were diagnosed as atopic-eczematous cheilitis. They were treated with 0.03 per cent topical tacrolimus ointment and responded completely.

CONCLUSIONS

These cases represent an underreported atopy / eczema event;-few cases of atopic cheilitis without concomitant dermal lesions appear in the literature. We are also showing and discussing yet another application of tacrolimus in a local atopic form of inflammation affecting the lips.

摘要

背景

剥脱性和糜烂性唇炎,可能是言语和咀嚼不适的原因,也可能是受影响患者的美学问题。这种临床表现可能涉及多种炎症性疾病,包括特应性(湿疹样)唇炎。局部和全身药物,如皮质类固醇,已被用于治疗炎症性唇病。局部他克莫司也已用于一些炎症性唇病。

材料和方法

我们对特应性唇炎患者进行了回顾性临床分析。

结果

2015 年至 2020 年间,我们共治疗了 7 例仅累及唇部的特应性皮炎患者,并诊断为特应性湿疹性唇炎。他们接受了 0.03%的他克莫司软膏治疗,完全缓解。

结论

这些病例代表了一种报道较少的特应性/湿疹事件;文献中很少有特应性唇炎而无伴随皮肤病变的病例。我们还展示和讨论了他克莫司在局部特应性炎症性唇炎中的另一种应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a8d/8141307/e6cc471779b8/medoral-26-e357-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a8d/8141307/9c70135ef1b1/medoral-26-e357-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a8d/8141307/e6cc471779b8/medoral-26-e357-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a8d/8141307/9c70135ef1b1/medoral-26-e357-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a8d/8141307/e6cc471779b8/medoral-26-e357-g002.jpg

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本文引用的文献

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Acta Clin Croat. 2018 Jun;57(2):342-351. doi: 10.20471/acc.2018.57.02.16.
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Tacrolimus ointment for the treatment of adult and pediatric atopic dermatitis: Review on safety and benefits.他克莫司软膏治疗成人和儿童特应性皮炎:安全性和疗效评价。
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Labial melanotic macule after application of topical tacrolimus: two case reports.外用他克莫司后唇部黑色素沉着斑:两例报告
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Squamous cell carcinoma in a patient with oral lichen planus treated with topical application of tacrolimus.一名口腔扁平苔藓患者外用他克莫司治疗后发生鳞状细胞癌。
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